Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.47 |
| ▸ | JAK1 | P23458 | 16/20 | 0.47 |
| ▸ | JAK3 | P52333 | 11/20 | 0.47 |
| ▸ | TYK2 | P29597 | 4/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.45 |
| ▸ | PAK4 | O96013 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | LTK | P29376 | 2/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.45 |
| ▸ | CLK2 | P49760 | 2/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.45 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145137 | 0.87 | JAK2 (0.49) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL102249 | 0.84 | JAK2 (0.51) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL15970056 | 0.83 | JAK1 (0.48) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL6122878 | 0.83 | JAK3 (0.48) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL103192 | 0.80 | JAK2 (0.49) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL29541213 | 0.80 | JAK2 (0.49) | JAK2JAK1JAK3TYK2RET | |
| Trifluoroacetic Acid SCHEMBL4093928 | 0.79 | JAK2 (0.47) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL101418 | 0.79 | JAK2 (0.51) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL101075 | 0.78 | EGFR (0.48) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL29540611 | 0.78 | EGFR (0.48) | JAK2JAK1JAK3TYK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426129-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2012-03-07 | — | — | EP | disclosed |