Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987116 | 0.86 | GCK (1.00) | GCK | |
| SCHEMBL9986965 | 0.79 | GCK (0.82) | GCK | |
| SCHEMBL9986665 | 0.79 | GCK (0.85) | GCKPTGS2 | |
| SCHEMBL9987128 | 0.79 | GCK (0.81) | GCK | |
| SCHEMBL9987239 | 0.78 | GCK (0.84) | GCK | |
| SCHEMBL9987029 | 0.76 | GCK (0.79) | GCK | |
| SCHEMBL9988133 | 0.76 | GCK (0.72) | GCK | |
| SCHEMBL9988134 | 0.76 | GCK (0.72) | GCK | |
| SCHEMBL9986994 | 0.74 | GCK (1.00) | GCK | |
| SCHEMBL9986909 | 0.74 | GCK (1.00) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | claimed |
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |