Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 8/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | FAAH | O00519 | 1/20 | 0.55 |
| ▸ | MCHR2 | Q969V1 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9986423 | 0.85 | TP53 (0.62) | TP53MAPTSMN1; SMN2THRBGAA | |
| SCHEMBL9987463 | 0.85 | TP53 (0.71) | TP53MAPTSMN1; SMN2THRBGAA | |
| SCHEMBL9986187 | 0.81 | TP53 (0.78) | TP53MAPTSMN1; SMN2THRBGAA | |
| SCHEMBL27275930 | 0.80 | MAPT (0.68) | TP53MAPTSMN1; SMN2THRBGAA | |
| SCHEMBL9987715 | 0.79 | TP53 (0.79) | TP53MAPTSMN1; SMN2THRBGAA | |
| SCHEMBL9986903 | 0.79 | TP53 (0.70) | TP53MAPTSMN1; SMN2THRBGAA | |
| SCHEMBL9986621 | 0.78 | TP53 (0.73) | TP53MAPTSMN1; SMN2THRBGAA | |
| SCHEMBL9986789 | 0.78 | TP53 (0.73) | TP53MAPTSMN1; SMN2THRBGAA | |
| SCHEMBL12158838 | 0.76 | KDM4E (0.66) | TP53MAPTSMN1; SMN2THRBGAA | |
| SCHEMBL10163400 | 0.76 | KDM4E (0.66) | TP53MAPTSMN1; SMN2THRBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |