Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | HRH2 | P25021 | 1/20 | 0.66 |
| ▸ | HRH1 | P35367 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4096055 | 0.94 | HRH3 (0.78) | HRH3KDM4EALDH1A1SMN1; SMN2HRH2 | |
| SCHEMBL12061358 | 0.94 | HRH3 (0.78) | HRH3KDM4EALDH1A1SMN1; SMN2HRH2 | |
| SCHEMBL4098927 | 0.94 | HRH3 (0.78) | HRH3KDM4EALDH1A1SMN1; SMN2HRH2 | |
| Water SCHEMBL25381550 | 0.93 | HRH3 (0.76) | HRH3KDM4EALDH1A1SMN1; SMN2HRH2 | |
| Water SCHEMBL25381549 | 0.93 | HRH3 (0.76) | HRH3KDM4EALDH1A1SMN1; SMN2HRH2 | |
| Oxalic Acid SCHEMBL20509708 | 0.85 | HRH3 (0.71) | HRH3KDM4EALDH1A1SMN1; SMN2HRH2 | |
| Oxalic Acid SCHEMBL4596486 | 0.85 | HRH3 (0.71) | HRH3KDM4EALDH1A1SMN1; SMN2HRH2 | |
| Oxalic Acid SCHEMBL20509707 | 0.85 | HRH3 (0.71) | HRH3KDM4EALDH1A1SMN1; SMN2HRH2 | |
| Oxalic Acid SCHEMBL4595185 | 0.85 | HRH3 (0.71) | HRH3KDM4EALDH1A1SMN1; SMN2HRH2 | |
| SCHEMBL4095149 | 0.85 | HRH3 (1.00) | HRH3KDM4EALDH1A1SMN1; SMN2HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076329-B2 | Histamine H3-receptor ligands and their therapeutic applications | BIOPROJET (FR) | 2011-12-13 | — | — | US | claimed |