Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987905 | 0.94 | KMT2A (0.54) | KAT6AKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL9987314 | 0.91 | KAT6A (0.57) | KAT6AKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL1785471 | 0.82 | KMT2A (0.69) | KMT2AALDH1A1MEN1MAPTTDP1 | |
| SCHEMBL30162751 | 0.81 | EPHX2 (0.59) | KAT6AKMT2AMEN1OPRK1EPHX2 | |
| SCHEMBL930213 | 0.81 | EPHX2 (0.59) | KAT6AKMT2AMEN1OPRK1EPHX2 | |
| SCHEMBL23487601 | 0.81 | POLB (0.65) | KMT2AALDH1A1MEN1MAPTTDP1 | |
| SCHEMBL931638 | 0.80 | EPHX2 (0.57) | KAT6AKMT2AMEN1OPRK1EPHX2 | |
| SCHEMBL30575465 | 0.80 | EPHX2 (0.57) | KAT6AKMT2AMEN1OPRK1EPHX2 | |
| SCHEMBL930820 | 0.80 | EPHX2 (0.57) | KAT6AKMT2AMEN1OPRK1EPHX2 | |
| SCHEMBL9005535 | 0.80 | EPHX2 (0.57) | KAT6AKMT2AMEN1OPRK1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |