Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9986633 | 0.81 | PDE4B (0.41) | KMT2APDE4BPDE4DENPP2NOTUM | |
| SCHEMBL9999343 | 0.81 | KMT2A (0.42) | KMT2APDE4BPDE4DMAPK14NOTUM | |
| SCHEMBL9987465 | 0.78 | KMT2A (0.45) | KMT2APDE4BPDE4DPDE4APDE4C | |
| SCHEMBL12035285 | 0.78 | KMT2A (0.39) | KMT2APDE4BPDE4DMAPK14ENPP2 | |
| SCHEMBL9987594 | 0.73 | KMT2A (0.45) | KMT2APDE4BPDE4DNOTUMPDE4A | |
| Trifluoroacetic Acid SCHEMBL9999316 | 0.70 | PIK3CD (0.43) | — | |
| Trifluoroacetic Acid SCHEMBL9999352 | 0.70 | PIK3CD (0.43) | — | |
| SCHEMBL12035341 | 0.70 | KMT2A (0.40) | KMT2APDE4BPDE4DPDE4AALDH1A1 | |
| SCHEMBL9987632 | 0.70 | KMT2A (0.48) | KMT2APDE4BPDE4DPDE4APDE4C | |
| SCHEMBL9987078 | 0.70 | NOTUM (0.39) | NOTUMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011163195-A1 | FUSED PYRROLE DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-12-29 | — | — | WO | disclosed |