Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 13/20 | 0.66 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.66 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.66 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.66 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.66 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.66 |
| ▸ | MAPK3 | P27361 | 7/20 | 0.58 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.54 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5383004 | 0.87 | MAP2K4 (0.68) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL14872686 | 0.86 | MAPK1 (0.65) | MAPK1MAP2K4MAPKAPK3MAPK6MAPK3 | |
| SCHEMBL3756031 | 0.85 | MAP2K4 (0.67) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL8437332 | 0.85 | MAP2K4 (0.84) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL5801309 | 0.85 | MAP2K4 (0.67) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL12074629 | 0.84 | MAPK1 (0.58) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| Hydrochloric Acid SCHEMBL27750633 | 0.84 | MAP2K4 (0.65) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| Potassium Ion SCHEMBL9986532 | 0.84 | MAPK1 (0.57) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL5388114 | 0.83 | MAP2K4 (0.56) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 | |
| SCHEMBL23559721 | 0.83 | MAP2K4 (0.58) | MAPK1MAP2K4MAPKAPK3MAPK6MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2584903-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011163330-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-12-29 | — | — | WO | disclosed |
| WO-2011163330-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-12-29 | — | — | WO | disclosed |