Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 19/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987460 | 1.00 | GCK (0.47) | GCKKCNH2PRSS1PRSS2PRSS3 | |
| SCHEMBL3598462 | 0.89 | GCK (0.55) | GCKKCNH2 | |
| SCHEMBL2664229 | 0.88 | GCK (0.50) | GCKKCNH2 | |
| SCHEMBL12070254 | 0.87 | GCK (0.44) | GCKKCNH2 | |
| SCHEMBL2664227 | 0.86 | GCK (0.53) | GCKKCNH2 | |
| SCHEMBL9986858 | 0.85 | GCK (0.45) | GCKKCNH2 | |
| SCHEMBL3595253 | 0.85 | GCK (0.45) | GCKKCNH2 | |
| SCHEMBL9986959 | 0.85 | GCK (0.59) | GCKKCNH2 | |
| SCHEMBL9986958 | 0.85 | GCK (0.59) | GCKKCNH2 | |
| SCHEMBL9071277 | 0.82 | GCK (0.56) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |