Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17574602 | 1.00 | KMT2A (0.41) | KMT2AHPGDPOLBMAPK1PDE2A | |
| SCHEMBL1443744 | 0.84 | KMT2A (0.42) | KMT2AHPGDPOLBMAPK1PDE2A | |
| SCHEMBL5548913 | 0.83 | KMT2A (0.41) | KMT2AHPGDPOLBPDE2AKIF11 | |
| SCHEMBL13104238 | 0.81 | POLB (0.43) | KMT2AHPGDPOLBMAPK1PDE2A | |
| SCHEMBL13677362 | 0.81 | POLB (0.43) | KMT2AHPGDPOLBMAPK1PDE2A | |
| SCHEMBL20339591 | 0.81 | PDE2A (0.54) | KMT2AHPGDPOLBMAPK1PDE2A | |
| SCHEMBL469235 | 0.81 | POLB (0.43) | KMT2AHPGDPOLBMAPK1PDE2A | |
| SCHEMBL23122207 | 0.80 | KMT2A (0.44) | KMT2AHPGDPOLBPDE2AKIF11 | |
| SCHEMBL9987929 | 0.80 | KMT2A (0.44) | KMT2AHPGDPOLBPDE2AKIF11 | |
| SCHEMBL22630752 | 0.80 | KMT2A (0.44) | KMT2AHPGDPOLBPDE2AKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018125810-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | DART NEUROSCIENCE, LLC (US) | 2018-07-05 | — | — | WO | disclosed |
| EP-1966156-B1 | NEW COMPOUNDS III | ASTRAZENECA AB (SE) | 2011-12-21 | — | — | EP | disclosed |