Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 20/20 | 0.61 |
| ▸ | CHUK | O15111 | 4/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5105950 | 0.90 | IKBKB (0.62) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL5113252 | 0.89 | IKBKB (0.63) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL5106110 | 0.89 | IKBKB (0.73) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL5105784 | 0.89 | IKBKB (0.61) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL5098758 | 0.88 | IKBKB (0.60) | IKBKBCHUKJAK2TYK2 | |
| SCHEMBL5113451 | 0.88 | IKBKB (0.63) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL5111880 | 0.88 | IKBKB (0.61) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL5103114 | 0.87 | IKBKB (0.62) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL9990925 | 0.87 | IKBKB (0.64) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL5098818 | 0.86 | IKBKB (0.59) | IKBKBCHUKJAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833836-B1 | IMIDAZO-FUSED THIAZOLO [4,5-B] PYRIDINE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | BRISTOL MYERS SQUIBB CO (US) | 2011-12-21 | — | — | EP | disclosed |