SCHEMBL9989664

SCHEMBL9989664

O=C1C=CC(=O)N1.O=S

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL715867 0.92 GSK3B (1.00)
SCHEMBL10990 0.92
SCHEMBL33524954 0.92
SCHEMBL1599522 0.92
SCHEMBL7021498 0.92
SCHEMBL693917 0.92 GSK3B (1.00)
Charcoal, Activated SCHEMBL4128314 0.88 GSK3A (0.92)
Charcoal, Activated SCHEMBL8357494 0.88
SCHEMBL4657701 0.88
SCHEMBL8835188 0.88

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2820013-A1 LIVER X RECEPTOR (LXR) MODULATORS FOR THE TREATMENT OF DERMAL DISEASES, DISORDERS AND CONDITIONS Alexar Therapeutics, Inc. (US) 2015-01-07 EP disclosed
EP-2797875-A1 CINNAMIC ACID HYDROXYAMIDES AS INHIBITORS OF HISTONE DEACETYLASE 8 Pharmacyclics, Inc. (US) 2014-11-05 EP disclosed
EP-2771010-A2 USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) Pharmacyclics, Inc. (US) 2014-09-03 EP disclosed
EP-2768810-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM Calcimedica, Inc. (US) 2014-08-27 EP disclosed
EP-2726077-A2 METHODS AND COMPOSITIONS FOR INHIBITION OF BONE RESORPTION Pharmacyclics, Inc. (US) 2014-05-07 EP disclosed
WO-2013130892-A1 LIVER X RECEPTOR (LXR) MODULATORS FOR THE TREATMENT OF DERMAL DISEASES, DISORDERS AND CONDITIONS ANAYADERM, INC. (US) 2013-09-06 WO disclosed
WO-2013101600-A1 CINNAMIC ACID HYDROXYAMIDES AS INHIBITORS OF HISTONE DEACETYLASE 8 PHARMACYCLICS, INC. (US) 2013-07-04 WO disclosed
WO-2013059738-A2 USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) PHARMACYCLICS, INC. (US) 2013-04-25 WO disclosed
WO-2013059666-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2013-04-25 WO disclosed
EP-2582374-A2 METHODS FOR TREATING NEUROLOGICAL CONDITIONS Afraxis, Inc. (US) 2013-04-24 EP disclosed
WO-2013003629-A2 METHODS AND COMPOSITIONS FOR INHIBITION OF BONE RESORPTION PHARMACYCLICS, INC. (US) 2013-01-03 WO disclosed
WO-2011159945-A2 METHODS FOR TREATING NEUROLOGICAL CONDITIONS AFRAXIS, INC. (US) 2011-12-22 WO disclosed