Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.35 |
| ▸ | HCK | P08631 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5585926 | 0.90 | KDR (0.44) | KDREPHB4TEKIRAK4MAPT | |
| SCHEMBL5586052 | 0.90 | KDR (0.44) | KDREPHB4TEKIRAK4MAPT | |
| SCHEMBL5586002 | 0.89 | KDR (0.43) | KDREPHB4TEKIRAK4MAPT | |
| SCHEMBL5592851 | 0.89 | EPHB4 (0.45) | KDREPHB4TEKIRAK4MAPT | |
| SCHEMBL5586061 | 0.88 | ERBB4 (0.44) | KDREPHB4TEKIRAK4MAPT | |
| SCHEMBL5592635 | 0.88 | KDR (0.43) | KDREPHB4TEKIRAK4MAPT | |
| SCHEMBL5586127 | 0.88 | KDR (0.43) | KDREPHB4TEKIRAK4MAPT | |
| SCHEMBL5592592 | 0.88 | KDR (0.45) | KDREPHB4TEKIRAK4MAPT | |
| Cyclopropane SCHEMBL9104235 | 0.88 | EPHB4 (0.43) | KDREPHB4TEKIRAK4MAPT | |
| SCHEMBL5585838 | 0.87 | KDR (0.43) | KDREPHB4TEKIRAK4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397478-A1 | 1,3-diaryl substituted ureas as modulators of kinase activity. | CGI Pharmaceuticals, Inc. (US) | 2011-12-21 | — | — | EP | disclosed |