Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 18/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.44 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.44 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391581 | 0.90 | MAP2K1 (0.55) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL19050688 | 0.85 | MAP2K1 (0.52) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL19050836 | 0.82 | MAP2K1 (0.45) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL392701 | 0.80 | MAP2K1 (0.61) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL4562609 | 0.78 | MAP2K1 (0.49) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL391551 | 0.77 | MAP2K1 (0.73) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL389794 | 0.77 | MAP2K1 (0.73) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL389793 | 0.77 | MAP2K1 (0.73) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL391190 | 0.75 | MAP2K1 (0.49) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL12656224 | 0.74 | MAP2K1 (0.49) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011128407-A9 | SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE-CONTAINING COMBINATIONS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2011-12-22 | — | — | WO | claimed |