Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9995335 | 1.00 | HDAC3 (0.54) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL443884 | 0.86 | SMN1; SMN2 (0.58) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL443882 | 0.86 | SMN1; SMN2 (0.58) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL443883 | 0.86 | SMN1; SMN2 (0.58) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL4834405 | 0.86 | SMN1; SMN2 (0.52) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL8282225 | 0.85 | SMN1; SMN2 (0.51) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL4828381 | 0.85 | SMN1; SMN2 (0.51) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL4837020 | 0.84 | HPGD (0.51) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL14181486 | 0.84 | HPGD (0.51) | HDAC3HDAC1HDAC2HDAC6HDAC10 | |
| SCHEMBL4867445 | 0.84 | HPGD (0.51) | HDAC3HDAC1HDAC2HDAC6HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140341989-A1 | FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR IN COMBINATION WITH BENDAMUSTINE AND USES THEREOF | LES LABORATOIRES SERVIER SAS (FR) | 2014-11-20 | — | — | US | claimed |
| US-20110311624-A1 | FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR AND USES THEREOF | PHARMACYCLICS, INC. (US) | 2011-12-22 | — | — | US | claimed |
| US-20190184196-A1 | FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR AND USES THEREOF | PHARMACYCLICS, INC. | 2019-06-20 | — | — | US | disclosed |
| US-10105552-B2 | Formulations of histone deacetylase inhibitor and uses thereof | PHARMACYCLICS LLC (US) | 2018-10-23 | — | — | US | disclosed |
| US-20170333731-A1 | FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR AND USES THEREOF | PHARMACYCLICS, INC. | 2017-11-23 | — | — | US | disclosed |
| US-9492423-B2 | Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof | PHARMACYCLICS LLC (US) | 2016-11-15 | — | — | US | disclosed |
| US-9403032-B2 | Formulations of histone deacetylase inhibitor and uses therof | PHARMACYCLICS LLC (US) | 2016-08-02 | — | — | US | disclosed |
| US-20150335609-A1 | COMBINATIONS OF HISTONE DEACETYLASE INHIBITOR AND PAZOPANIB AND USES THEREOF | PHARMACYCLICS LLC | 2015-11-26 | — | — | US | disclosed |
| US-20150164854-A1 | FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR AND USES THEROF | PHARMACYCLICS LLC | 2015-06-18 | — | — | US | disclosed |
| US-20140341989-A1 | FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR IN COMBINATION WITH BENDAMUSTINE AND USES THEREOF | LES LABORATOIRES SERVIER SAS (FR) | 2014-11-20 | — | — | US | disclosed |
| US-20140057862-A1 | FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR AND USES THEROF | PHARMACYCLICS, INC. (US) | 2014-02-27 | — | — | US | disclosed |
| US-8603521-B2 | Formulations of histone deacetylase inhibitor and uses thereof | PHARMACYCLICS, INC. (US) | 2013-12-10 | — | — | US | disclosed |
| US-20110311624-A1 | FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR AND USES THEREOF | PHARMACYCLICS, INC. (US) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110311624-A1 | FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR AND USES THEREOF | HDAC1, HDAC7, HDAC5 | HDAC3 7/4885HDAC1 1/4885HDAC2 5/4885 |
| US-20150164854-A1 | FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR AND USES THEROF | HDAC1, HDAC2, HDAC8 | HDAC3 5/4885HDAC1 1/4885HDAC2 2/4885 |
| US-20170333731-A1 | FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR AND USES THEREOF | HDAC1, HDAC7, HDAC5 | HDAC3 7/4885HDAC1 1/4885HDAC2 5/4885 |
| US-20140341989-A1 | FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR IN COMBINATION WITH BENDAMUSTINE AND USES THEREOF | HDAC5, HDAC7, HDAC4 | HDAC3 11/4885HDAC1 7/4885HDAC2 8/4885 |
| US-20140057862-A1 | FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR AND USES THEROF | HDAC1, HDAC2, HDAC8 | HDAC3 5/4885HDAC1 1/4885HDAC2 2/4885 |
| US-10105552-B2 | Formulations of histone deacetylase inhibitor and uses thereof | HDAC1, HDAC7, HDAC5 | HDAC3 7/4885HDAC1 1/4885HDAC2 5/4885 |
| US-20150335609-A1 | COMBINATIONS OF HISTONE DEACETYLASE INHIBITOR AND PAZOPANIB AND USES THEREOF | HDAC3, HDAC5, HDAC4 | HDAC3 1/4885HDAC1 4/4885HDAC2 10/4885 |
| US-20190184196-A1 | FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR AND USES THEREOF | HDAC1, HDAC7, HDAC5 | HDAC3 7/4885HDAC1 1/4885HDAC2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.