SCHEMBL9995608

SCHEMBL9995608

CCCCCCC1=C(c2ccc(F)cc2)CCCc2cc(OC)ccc21

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 7/20 0.45
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
MPO P05164 1/20 0.38
HTR2A P28223 1/20 0.38
CYP19A1 P11511 2/20 0.36
CYP11B2 P19099 2/20 0.36
PTGS1 P23219 2/20 0.36
PTGS2 P35354 2/20 0.36
EBP Q15125 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
GHSR Q92847 1/20 0.35
MAPK14 Q16539 2/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
KMT2A Q03164 1/20 0.35
TDP1 Q9NUW8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12072305 0.90 ESR1 (0.47) ESR1MAOAMAOBMPOCYP19A1
SCHEMBL15263129 0.90 ESR1 (0.47) ESR1MAOAMAOBMPOCYP19A1
SCHEMBL9995589 0.87 MAPK14 (0.39) ESR1MAOAMAOBMPOHTR2A
SCHEMBL3849269 0.84 ESR1 (0.57) ESR1MAOAMAOBMPOEBP
SCHEMBL3847255 0.84 ESR1 (0.52) ESR1MPOCYP19A1CYP11B2PTGS1
SCHEMBL15028586 0.83 ESR1 (0.50) ESR1MPOCYP19A1CYP11B2PTGS1
SCHEMBL15028666 0.83 ESR1 (0.50) ESR1MPOCYP19A1CYP11B2PTGS1
SCHEMBL9995795 0.82 ESR1 (0.42) ESR1MPOCYP19A1CYP11B2EBP
SCHEMBL12072291 0.80 ESR1 (0.43) ESR1MAOAMAOBMPOCYP19A1
SCHEMBL9995705 0.80 ESR1 (0.43) ESR1CYP19A1CYP11B2PTGS1PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2585435-A1 6,7-DIHYDRO-5H-BENZO[7]ANNULENE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, PHARMACEUTICAL PREPARATIONS COMPRISING THEM, AND THE USE THEREOF FOR PRODUCTION OF MEDICAMENTS Bayer Intellectual Property GmbH (DE) 2013-05-01 EP disclosed
WO-2011161101-A1 6,7-DIHYDRO-5H-BENZO[7]ANNULENE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, PHARMACEUTICAL PREPARATIONS COMPRISING THEM, AND THE USE THEREOF FOR PRODUCTION OF MEDICAMENTS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2011-12-29 WO disclosed