Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 4/20 | 0.66 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.50 |
| ▸ | ALPI | P09923 | 1/20 | 0.50 |
| ▸ | ALPG | P10696 | 1/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9997289 | 0.93 | PFKFB3 (0.61) | PFKFB3MCL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL9997213 | 0.92 | PFKFB3 (0.66) | PFKFB3MCL1ALDH1A1HSD17B10HSD17B2 | |
| SCHEMBL9997986 | 0.90 | PFKFB3 (0.71) | PFKFB3MCL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL9996891 | 0.89 | PFKFB3 (0.67) | PFKFB3MCL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL9996845 | 0.88 | PFKFB3 (0.64) | PFKFB3MCL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL9996789 | 0.88 | PFKFB3 (0.69) | PFKFB3MCL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL9996882 | 0.87 | PFKFB3 (0.69) | PFKFB3MCL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL9997151 | 0.86 | PFKFB3 (0.65) | PFKFB3MCL1ALDH1A1HSD17B10MEN1 | |
| SCHEMBL9996926 | 0.86 | PFKFB3 (0.66) | PFKFB3MCL1ALDH1A1HSD17B10HPGD | |
| SCHEMBL9997323 | 0.86 | PFKFB3 (0.66) | PFKFB3MCL1ALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011161201-A1 | BISARYLSULFONAMIDES USEFUL AS KINASE INHIBITORS IN THE TREATMENT OF INFLAMMATION AND CANCER | KANCERA AB (SE) | 2011-12-29 | — | — | WO | claimed |
| WO-2020080979-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO DISCOVERY LIMITED LIABILITY COMPANY (RU) | 2020-04-23 | — | — | WO | disclosed |
| WO-2011161201-A1 | BISARYLSULFONAMIDES USEFUL AS KINASE INHIBITORS IN THE TREATMENT OF INFLAMMATION AND CANCER | KANCERA AB (SE) | 2011-12-29 | — | — | WO | disclosed |
| WO-2011161201-A1 | BISARYLSULFONAMIDES USEFUL AS KINASE INHIBITORS IN THE TREATMENT OF INFLAMMATION AND CANCER | KANCERA AB (SE) | 2011-12-29 | — | — | WO | disclosed |