Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4168126 | 0.82 | HRH4 (0.53) | HRH4 | |
| SCHEMBL603509 | 0.82 | HRH4 (0.55) | HRH4 | |
| SCHEMBL605352 | 0.81 | HRH4 (0.41) | HRH4 | |
| SCHEMBL604317 | 0.78 | HRH4 (0.40) | NPC1KDM4ERAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL605703 | 0.76 | HRH4 (0.46) | HRH4CXCR3 | |
| SCHEMBL605193 | 0.76 | HRH4 (0.38) | NPC1KDM4ERAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL603878 | 0.74 | HRH4 (0.41) | NPC1KDM4ERAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL604091 | 0.74 | HRH4 (0.39) | HRH4CXCR3KDR | |
| SCHEMBL606639 | 0.74 | HRH4 (0.39) | NPC1KDM4ERAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL601656 | 0.73 | HRH4 (0.42) | HRH4FGFR1FLT1PDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084466-B2 | Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2011-12-27 | — | — | US | claimed |