Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 14/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2301918 | 0.79 | PIK3CG (0.61) | PIK3CGPIK3CD | |
| SCHEMBL2300343 | 0.79 | PIK3CD (0.62) | PIK3CGPIK3CDALDH1A1MAPK1PTK2B | |
| SCHEMBL2303766 | 0.78 | PIK3CG (0.73) | PIK3CGPIK3CD | |
| SCHEMBL2301815 | 0.77 | PIK3CG (0.61) | PIK3CGPIK3CD | |
| SCHEMBL2300757 | 0.77 | PIK3CG (0.72) | PIK3CGPIK3CD | |
| SCHEMBL2301020 | 0.76 | PIK3CD (0.72) | PIK3CGPIK3CDALDH1A1MAPK1PTK2B | |
| SCHEMBL2303925 | 0.76 | PIK3CD (0.69) | PIK3CGPIK3CD | |
| SCHEMBL188285 | 0.76 | PIK3CD (0.81) | PIK3CGPIK3CDALDH1A1 | |
| SCHEMBL2281079 | 0.75 | PIK3C2B (0.76) | PIK3CGPIK3CD | |
| SCHEMBL2300182 | 0.74 | PIK3CD (0.60) | PIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877757-B2 | Pyrazine derivatives and use as PI3K inhibitors | MERCK SERONO SA (CH) | 2014-11-04 | — | — | US | disclosed |
| US-20110312960-A1 | PYRAZINE DERIVATIVES AND USE AS PI3K INHIBITORS | MERCK SERONO SA (CH) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312960-A1 | PYRAZINE DERIVATIVES AND USE AS PI3K INHIBITORS | PIK3R5, PIK3CD, PIK3CA | PIK3CG 4/4885PIK3CD 2/4885ALDH1A1 2357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.