Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18609854 | 1.00 | CNR2 (0.43) | CNR2TP53CCR6CHRM1KMT2A | |
| SCHEMBL16727612 | 1.00 | CNR2 (0.43) | CNR2TP53CCR6CHRM1KMT2A | |
| SCHEMBL2586547 | 1.00 | CNR2 (0.43) | CNR2TP53CCR6CHRM1KMT2A | |
| SCHEMBL3342354 | 0.87 | KMT2A (0.44) | TP53KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL29766207 | 0.87 | CNR2 (0.41) | CNR2KMT2ATSHRMEN1KDM4E | |
| SCHEMBL18532604 | 0.87 | CNR2 (0.41) | CNR2KMT2ATSHRMEN1KDM4E | |
| SCHEMBL2583006 | 0.87 | CNR2 (0.41) | CNR2KMT2ATSHRMEN1KDM4E | |
| SCHEMBL17997997 | 0.87 | CNR2 (0.41) | CNR2KMT2ATSHRMEN1KDM4E | |
| SCHEMBL18532542 | 0.87 | CNR2 (0.41) | CNR2KMT2ATSHRMEN1KDM4E | |
| SCHEMBL2583648 | 0.85 | CNR2 (0.46) | CNR2TP53CCR6CHRM1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4015504-A1 | C5AR ANTAGONISTS | ChemoCentryx, Inc. (US) | 2022-06-22 | — | — | EP | disclosed |
| EP-3508477-A1 | C5AR ANTAGONISTS | ChemoCentryx, Inc. (US) | 2019-07-10 | — | — | EP | disclosed |
| EP-3078658-B1 | C5AR ANTAGONISTS | CHEMOCENTRYX INC (US) | 2019-04-10 | — | — | EP | disclosed |
| EP-2585064-A1 | C5AR ANTAGONISTS | ChemoCentryx, Inc. (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011163640-A1 | C5AR ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2011-12-29 | — | — | WO | disclosed |