Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318780 | 0.96 | MEN1 (0.69) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL318671 | 0.91 | MEN1 (0.65) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL318383 | 0.91 | MEN1 (0.74) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL318898 | 0.87 | MEN1 (0.58) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL318397 | 0.87 | MEN1 (0.57) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL18601859 | 0.86 | MEN1 (0.57) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL318573 | 0.85 | KCNH2 (0.56) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL319063 | 0.84 | MEN1 (0.54) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9999009 | 0.84 | MEN1 (0.78) | MEN1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL318273 | 0.83 | MEN1 (0.63) | MEN1TP53CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582701-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011160084-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2011-12-22 | — | — | WO | disclosed |