Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 6/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9986601 | 0.94 | PIK3CD (0.46) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| Trifluoroacetic Acid SCHEMBL9999148 | 0.87 | PIK3CD (0.42) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| Trifluoroacetic Acid SCHEMBL9999180 | 0.87 | PIK3CD (0.46) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| Trifluoroacetic Acid SCHEMBL9999345 | 0.86 | PIK3CD (0.41) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| Trifluoroacetic Acid SCHEMBL9986461 | 0.84 | PIK3CD (0.46) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| Trifluoroacetic Acid SCHEMBL9986345 | 0.84 | PIK3CD (0.46) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| Trifluoroacetic Acid SCHEMBL9986354 | 0.82 | PIK3CD (0.45) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| Trifluoroacetic Acid SCHEMBL9999103 | 0.82 | PIK3CD (0.43) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| Trifluoroacetic Acid SCHEMBL9999352 | 0.81 | PIK3CD (0.43) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| Trifluoroacetic Acid SCHEMBL9999316 | 0.81 | PIK3CD (0.43) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9062055-B2 | Fused pyrrole derivatives as PI3K inhibitors | INCYTE CORPORATION (US) | 2015-06-23 | — | — | US | disclosed |
| US-20110312979-A1 | FUSED PYRROLE DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312979-A1 | FUSED PYRROLE DERIVATIVES AS PI3K INHIBITORS | PIK3R5, PIK3R4, PIK3CA | PIK3CD 8/4885PIK3CG 12/4885PIK3CA 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.