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Sugi Predict / Targets / AARS1

AARS1

Alanine--tRNA ligase, cytoplasmic · P49588 · AARS1 on Sugi Atlas →

0 patent compounds predicted against AARS1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to AARS1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy PHASE2/PHASE3UNKNOWN
Bezafibrate Trial in CPT2 Deficiency PHASE3UNKNOWN
Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene. PHASE1/PHASE2COMPLETED
Reverse Transcriptase Inhibitors in AGS PHASE2COMPLETED
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC PHASE2COMPLETED
Personalized Antisense Oligonucleotide for A Single Participant With GARS1 Gene Mutation Associated With Charcot-Marie-Tooth Disease Type 2D (CMT2D) PHASE1/PHASE2ENROLLING_BY_INVITATION
Cholic Acid for Hepatic Steatosis in Lipodystrophy PHASE2COMPLETED
Tolerability of Enteral NAC in Infants PHASE1NOT_YET_RECRUITING
Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL) nanRECRUITING
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress nanWITHDRAWN
Quantifying Disease Progression in LBSL nanUNKNOWN
Natural History Study of FDXR Mutation-related Mitochondriopathy nanCOMPLETED
Effect of Branched Chain Amino Acids on Muscle nanCOMPLETED
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease nanUNKNOWN
Screening of Lysosomal Storage Disorders Diseases in Minority Groups nanUNKNOWN
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML) nanCOMPLETED
The Role of Ectopic Fat and Heart Attack Risk in HIV nanRECRUITING
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy nanUNKNOWN
Genomic of CONgenital Sideroblastic Anemias nanRECRUITING
Positional Cloning of the Gene(s) Responsible for Alagille Syndrome nanCOMPLETED
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure nanUNKNOWN
Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase. nanUNKNOWN
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes nanRECRUITING
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic nanCOMPLETED
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence nanNOT_YET_RECRUITING
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide nanRECRUITING
Identification of a New Gene Involved in Hereditary Lipodystrophy nanCOMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia nanNOT_YET_RECRUITING
Intermittent Fasting for Pancreatitis nanNOT_YET_RECRUITING
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION

Related proteins — ESM-2 sequence neighbours (a AARS1 binder may also engage these)

ProteinNameSimilarity
Q8CFX8 — 1.000 Q8CFX8 →
Q5RC02 — 1.000 Q5RC02 →
P50475 — 1.000 P50475 →
Q8BGQ7 — 1.000 Q8BGQ7 →
Q9VLM8 — 1.000 Q9VLM8 →
O01541 — 1.000 O01541 →
P21894 — 1.000 P21894 →
Q54Y20 — 0.996 Q54Y20 →
Q5A8K2 — 0.994 Q5A8K2 →
P40825 — 0.993 P40825 →
Q5AQL1 — 0.993 Q5AQL1 →
Q5M126 — 0.992 Q5M126 →
O13914 — 0.992 O13914 →
Q1JL53 — 0.992 Q1JL53 →
Q2SBT9 — 0.992 Q2SBT9 →
Q6FCT2 — 0.991 Q6FCT2 →
P57933 — 0.991 P57933 →
A1T001 — 0.991 A1T001 →
P36428 — 0.991 P36428 →
Q03LZ8 — 0.991 Q03LZ8 →
A6LEZ8 — 0.991 A6LEZ8 →
Q48SS4 — 0.991 Q48SS4 →
Q99Z57 — 0.991 Q99Z57 →
B1JJA0 — 0.991 B1JJA0 →
A4W221 — 0.991 A4W221 →
Q487H5 — 0.991 Q487H5 →
Q885J0 — 0.990 Q885J0 →
A1TZ92 — 0.990 A1TZ92 →
Q1JB08 — 0.990 Q1JB08 →
F4IFC5 — 0.990 F4IFC5 →