Sugi Predict

Sugi Predict / Targets / ACLY

ACLY

ATP-citrate synthase · P53396 · ACLY on Sugi Atlas →

47,638 patent compounds predicted against ACLY, 23,988 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL184807 SCHEMBL184807 0.74 18/20
SCHEMBL94411 SCHEMBL94411 0.70 18/20
SCHEMBL184271 SCHEMBL184271 0.62 18/20
SCHEMBL184836 SCHEMBL184836 0.53 17/20
SCHEMBL252052 SCHEMBL252052 0.60 16/20
SCHEMBL185035 SCHEMBL185035 0.55 16/20
SCHEMBL184486 SCHEMBL184486 0.53 16/20
SCHEMBL184797 SCHEMBL184797 0.48 16/20
SCHEMBL184772 SCHEMBL184772 0.70 14/20
SCHEMBL184677 SCHEMBL184677 0.63 14/20
SCHEMBL184787 SCHEMBL184787 0.56 14/20
SCHEMBL184080 SCHEMBL184080 0.53 14/20
SCHEMBL184855 SCHEMBL184855 0.45 14/20
SCHEMBL252751 SCHEMBL252751 0.71 13/20
SCHEMBL184307 SCHEMBL184307 0.66 13/20
SCHEMBL184545 SCHEMBL184545 0.52 13/20
SCHEMBL183989 SCHEMBL183989 0.52 13/20
SCHEMBL185047 SCHEMBL185047 0.80 12/20
SCHEMBL184586 SCHEMBL184586 0.65 12/20
SCHEMBL184069 SCHEMBL184069 0.59 12/20

Clinical trials — most relevant to ACLY by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Glutamate for Metabolic Intervention in Coronary Surgery PHASE3COMPLETED
Venetoclax+HMA+Aclarubicin Versus Venetoclax+HMA in Treatment-Naive Elderly Patients With AML PHASE3UNKNOWN
Chronic Versus Acute Dosing of Sodium Citrate for Swimming 200m PHASE3COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients PHASE2COMPLETED
Testosterone and Physical Function in HIV+ Men PHASE2COMPLETED
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease PHASE2COMPLETED
In Vivo Assessment of Cellular Metabolism in Humans PHASE1COMPLETED
Lifestyle Intervention in Preparation for Pregnancy (LIPP) nanCOMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Exercise, Statins, and the Metabolic Syndrome nanCOMPLETED
Mitoquines in COPD nanUNKNOWN
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
11C-Acetate PET/CT Non-FDG-Avid Tumors nanUNKNOWN
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP) nanNOT_YET_RECRUITING
Multi-omics Study in Citrin Deficiency nanACTIVE_NOT_RECRUITING
Mitochondrial Methylation in Type 2 Diabetes nanCOMPLETED
Lactate Profile and Fat Oxidation During Exercise nanCOMPLETED
Studying Samples From Patients With T-Cell Acute Lymphoblastic Leukemia nanCOMPLETED
MOLECULAR REGULATION OF MUSCLE GLUCOSE METABOLISM (AIMS 2A, 2B, 3) nanUNKNOWN
Screening of IDH1 and IDH2 Gene Mutations in Adult Acute Myeloid Leukemia for Possible Targeted Therapy nanUNKNOWN
Examining The Effect of Blood Flow Restricted Aerobic Training on Mitochondrial Adaptations in Young Healthy Adults nanCOMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Hepatic Energy Fluxes in NASH and NAS Patients nanACTIVE_NOT_RECRUITING
Alpha-Ketoglutarate and Abdominal Aortic Aneurysm Progression and Rupture nanRECRUITING
Triheptanoin (UX007) to Treat Citrate Transporter Deficiency nanNO_LONGER_AVAILABLE

Related proteins — ESM-2 sequence neighbours (a ACLY binder may also engage these)

ProteinNameSimilarity
P16638 — 1.000 P16638 →
Q91V92 — 1.000 Q91V92 →
Q32PF2 — 1.000 Q32PF2 →
Q2TCH3 — 1.000 Q2TCH3 →
P53585 — 1.000 P53585 →
Q9P7W3 — 0.995 Q9P7W3 →
O93988 — 0.994 O93988 →
P00927 — 0.993 P00927 →
Q9FGX1 — 0.993 Q9FGX1 →
Q9C522 — 0.993 Q9C522 →
O93918 — 0.992 O93918 →
Q6AVG6 — 0.992 Q6AVG6 →
A0A4P8DJE6 — 0.992 A0A4P8DJE6 →
Q8X097 — 0.992 Q8X097 →
Q8X1T3 — 0.991 Q8X1T3 →
Q93VT8 — 0.991 Q93VT8 →
O88428 — 0.991 O88428 →
Q0CLK1 — 0.990 Q0CLK1 →
P0DA07 — 0.990 P0DA07 →
P32327 — 0.990 P32327 →
Q9UUE1 — 0.990 Q9UUE1 →
P28240 — 0.990 P28240 →
Q612F5 — 0.990 Q612F5 →
P16862 — 0.990 P16862 →
O82399 — 0.989 O82399 →
O94489 — 0.989 O94489 →
Q9SSK1 — 0.989 Q9SSK1 →
P13228 — 0.989 P13228 →
Q9SC14 — 0.989 Q9SC14 →
P19446 — 0.989 P19446 →