ACOX3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Alectinib (SCHEMBL896753)	1.00	1/20
Rebastinib (SCHEMBL2034290)	1.00	1/20
Rebastinib (SCHEMBL2026623)	0.99	1/20
SCHEMBL896761	0.90	1/20
SCHEMBL2024402	0.89	1/20
SCHEMBL898391	0.88	1/20
SCHEMBL898293	0.87	1/20
SCHEMBL897920	0.87	1/20
SCHEMBL898091	0.87	1/20
SCHEMBL2029025	0.86	1/20
SCHEMBL1703476	0.85	1/20
SCHEMBL898225	0.85	1/20
SCHEMBL897434	0.84	1/20
SCHEMBL897844	0.84	1/20
SCHEMBL898093	0.83	1/20
SCHEMBL897678	0.83	1/20
SCHEMBL2028677	0.83	1/20
SCHEMBL897477	0.83	1/20
Hydrochloric Acid (SCHEMBL2029657)	0.83	1/20
Hydrochloric Acid (SCHEMBL2031193)	0.82	1/20

Clinical trials — most relevant to ACOX3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Omega 3 and Ischemic Stroke; Fish Oil as an Option	PHASE4	UNKNOWN
Effect of Pioglitazone Administered to Patients With Friedreich's Ataxia: Proof of Concept	PHASE3	COMPLETED
Betaine and Peroxisome Biogenesis Disorders	PHASE3	COMPLETED
Bezafibrate Trial in CPT2 Deficiency	PHASE3	UNKNOWN
Effect of Bezafibrate on Muscle Metabolism in Patients With Fatty Acid Oxidation Defects	PHASE2	COMPLETED
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease	PHASE2	COMPLETED
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
The Effects of Coenzyme A Combined With Abiraterone on Patients With CRPC	PHASE1/PHASE2	UNKNOWN
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study	nan	COMPLETED
Fatty Acid Oxidation Defects and Insulin Sensitivity	nan	COMPLETED
Hepatic Energy Fluxes in NASH and NAS Patients	nan	ACTIVE_NOT_RECRUITING
Lifestyle Intervention in Preparation for Pregnancy (LIPP)	nan	COMPLETED
Genetics in the Effect of Caffeine on Fat Oxidation	nan	COMPLETED
Promotion of Weight Management	nan	ACTIVE_NOT_RECRUITING
Fatty Acid Metabolism and Insulin Sensitivity: the Role of Endurance Exercise	nan	COMPLETED
Effect of a PPAR-Alpha Agonist on the Age Related Changes in Myocardial Metabolism and Mechanical Function	nan	UNKNOWN
Effects of Fish Oils on Inflammation and Insulin Resistance	nan	COMPLETED
High Fat Diet for Cardiac Metabolic Reprogramming	nan	RECRUITING
Omega-3 vs Very Low Calorie Diet for Liver Size Reduction	nan	UNKNOWN
Saturated Fat Versus Monounsaturated Fat and Insulin Action	nan	COMPLETED
Study of Protein Translocation in Patients With Beta-Oxidation Disorders	nan	COMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
Exercise Intolerance Study in Long Chain Fatty Acid Oxidation Disorders	nan	RECRUITING
Genetical Background of Non-alcoholic Fatty Liver Disease (NAFLD) in Diabetes Mellitus and in Chronic Kidney Disease	nan	UNKNOWN
Re-energize With Nutrition, Exercise and Weight Loss	nan	COMPLETED
Omics-based Predictors of NAFLD/Potential NASH	nan	UNKNOWN
Evaluation of a New Strategy for the Diagnosis of Peroxisomal Diseases	nan	COMPLETED
Effect of SGLT2 Inhibitors on NAFLD in Type 2 Diabetic Patients with Diabetic Nephropathy	nan	NOT_YET_RECRUITING
Observational Study to Assess Glycosylated Hemoglobin Changes After 6 Months of Treatment With Pioglitazone.	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ACOX3 binder may also engage these)

Protein	Name	Similarity
Q5RAU0	—	1.000	Q5RAU0 →
Q9EPL9	—	1.000	Q9EPL9 →
Q63448	—	0.997	Q63448 →
P07872	—	0.989	P07872 →
Q5RC19	—	0.989	Q5RC19 →
ACOX1	Peroxisomal acyl-coenzyme A oxidase 1	0.988	landscape →
O65202	—	0.988	O65202 →
O64894	—	0.988	O64894 →
O65201	—	0.987	O65201 →
Q8HYL8	—	0.987	Q8HYL8 →
O02767	—	0.987	O02767 →
Q9QXD1	—	0.987	Q9QXD1 →
Q9Z1N0	—	0.987	Q9Z1N0 →
O62137	—	0.984	O62137 →
Q99424	—	0.984	Q99424 →
Q9DBS4	—	0.984	Q9DBS4 →
Q9R0H0	—	0.983	Q9R0H0 →
P0CZ23	—	0.983	P0CZ23 →
P97562	—	0.983	P97562 →
Q9LMI7	—	0.983	Q9LMI7 →
Q3SZP5	—	0.982	Q3SZP5 →
Q9ZQP2	—	0.982	Q9ZQP2 →
O62139	—	0.980	O62139 →
Q20992	—	0.980	Q20992 →
Q7KML2	—	0.978	Q7KML2 →
O74934	—	0.978	O74934 →
O62138	—	0.978	O62138 →
Q8K370	—	0.976	Q8K370 →
P34355	—	0.976	P34355 →
Q5ZHT1	—	0.976	Q5ZHT1 →