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Sugi Predict / Targets / ACSS2

ACSS2

Acetyl-coenzyme A synthetase, cytoplasmic · Q9NR19 · ACSS2 on Sugi Atlas →

10,445 patent compounds predicted against ACSS2, 4,135 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL5194344 SCHEMBL5194344 0.53 19/20
SCHEMBL1259831 SCHEMBL1259831 0.47 15/20
SCHEMBL2524929 SCHEMBL2524929 0.41 13/20
SCHEMBL2524938 SCHEMBL2524938 0.41 13/20
SCHEMBL4024055 SCHEMBL4024055 0.44 12/20
SCHEMBL2248751 SCHEMBL2248751 0.50 11/20
SCHEMBL2251168 SCHEMBL2251168 0.50 11/20
SCHEMBL1260127 SCHEMBL1260127 0.43 10/20
SCHEMBL1249330 SCHEMBL1249330 0.49 9/20
SCHEMBL361774 SCHEMBL361774 0.38 9/20
SCHEMBL1390277 SCHEMBL1390277 0.38 9/20
SCHEMBL1390279 SCHEMBL1390279 0.38 9/20
SCHEMBL4223848 SCHEMBL4223848 0.51 8/20
SCHEMBL1260363 SCHEMBL1260363 0.45 8/20
SCHEMBL4028853 SCHEMBL4028853 0.41 8/20
SCHEMBL1080147 SCHEMBL1080147 0.48 7/20
SCHEMBL3199540 SCHEMBL3199540 0.48 7/20
SCHEMBL3131701 SCHEMBL3131701 0.48 7/20
SCHEMBL5359370 SCHEMBL5359370 0.45 7/20
SCHEMBL774480 SCHEMBL774480 0.39 7/20

Clinical trials — most relevant to ACSS2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effects of Fenofibrate Therapy in Diabetic Nephropathy PHASE3UNKNOWN
The Effects of Coenzyme A Combined With Abiraterone on Patients With CRPC PHASE1/PHASE2UNKNOWN
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease PHASE2COMPLETED
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients PHASE2COMPLETED
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis PHASE2UNKNOWN
Clinical Trial of 2-HOBA in Pulmonary Arterial Hypertension PHASE2NOT_YET_RECRUITING
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
Lifestyle Intervention in Preparation for Pregnancy (LIPP) nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
11C-Acetate PET/CT Non-FDG-Avid Tumors nanUNKNOWN
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
MOLECULAR REGULATION OF MUSCLE GLUCOSE METABOLISM (AIMS 2A, 2B, 3) nanUNKNOWN
Hepatic Energy Fluxes in NASH and NAS Patients nanACTIVE_NOT_RECRUITING
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress nanWITHDRAWN
Fatty Acid Oxidation Defects and Insulin Sensitivity nanCOMPLETED
Effect of Age on Glucose and Lipid Metabolism nanCOMPLETED
Multi-omics Study in Citrin Deficiency nanACTIVE_NOT_RECRUITING
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Tissue Lipids and Insulin Resistance nanWITHDRAWN
Epicardial Fat Tissue and Severity of Coronary Artery Disease in Diabetic vs Non Diabetic Patients nanUNKNOWN
The Role of Ectopic Fat and Heart Attack Risk in HIV nanRECRUITING
Effect of Cocoa Polyphenols Supplementation on Cardiovascular Risk of Postmenopausal Women nanUNKNOWN
Role of Dairy Products in Weight Maintenance nanCOMPLETED
Screening of Healthy Adults for Genetic Variations That Control Fatty Acid Processing nanCOMPLETED
A Case Control Study Evaluating the Prevalence of Non-Alcoholic Fatty Liver Disease Among Patients With Psoriasis nanCOMPLETED
Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection. nanCOMPLETED
Epidemiology of Atherosclerosis nanCOMPLETED
Nephroprotective Effects of Carnitine and (PDE5) Inhibitor Agent Against Contrast Media-induced Nephropathy (CMN) nanUNKNOWN
The Safety and Efficacy Study of RiaGev in Healthy Adults nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a ACSS2 binder may also engage these)

ProteinNameSimilarity
Q9QXG4 — 1.000 Q9QXG4 →
Q9NUB1 — 0.995 Q9NUB1 →
Q99NB1 — 0.995 Q99NB1 →
Q6FLU2 — 0.995 Q6FLU2 →
Q54Z60 — 0.994 Q54Z60 →
B9DGD6 — 0.993 B9DGD6 →
Q01574 — 0.993 Q01574 →
Q9H6R3 — 0.992 Q9H6R3 →
Q6BQF2 — 0.992 Q6BQF2 →
Q758X0 — 0.992 Q758X0 →
O60011 — 0.992 O60011 →
A7MB45 — 0.991 A7MB45 →
Q5REB8 — 0.991 Q5REB8 →
B8FIN2 — 0.991 B8FIN2 →
Q8NJN3 — 0.991 Q8NJN3 →
Q9Y7B5 — 0.990 Q9Y7B5 →
Q27549 — 0.990 Q27549 →
O94049 — 0.990 O94049 →
Q7MBA6 — 0.990 Q7MBA6 →
Q01576 — 0.990 Q01576 →
A1JIK3 — 0.990 A1JIK3 →
Q6FXI2 — 0.990 Q6FXI2 →
Q6BS00 — 0.989 Q6BS00 →
P27550 — 0.989 P27550 →
O68040 — 0.989 O68040 →
Q1C0N0 — 0.989 Q1C0N0 →
Q96VC7 — 0.989 Q96VC7 →
Q9CMW1 — 0.989 Q9CMW1 →
Q9VP61 — 0.989 Q9VP61 →
P16928 — 0.989 P16928 →