ACTR2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Talmapimod (SCHEMBL2369829)	1.00	1/20
Talmapimod (SCHEMBL4779238)	1.00	1/20
Talmapimod (SCHEMBL4779242)	1.00	1/20
SCHEMBL4503552	0.83	1/20
SCHEMBL4512542	0.83	1/20
SCHEMBL4511919	0.71	1/20
SCHEMBL4501638	0.71	1/20
SCHEMBL4500434	0.68	1/20
SCHEMBL4488337	0.67	1/20
SCHEMBL4511329	0.67	1/20
SCHEMBL4496173	0.65	1/20
SCHEMBL4506839	0.65	1/20
SCHEMBL4488618	0.64	1/20
SCHEMBL4498276	0.64	1/20
SCHEMBL4514087	0.64	1/20
SCHEMBL4514094	0.64	1/20
SCHEMBL4499019	0.63	1/20
SCHEMBL4499838	0.61	1/20
SCHEMBL4503450	0.60	1/20
SCHEMBL4488849	0.60	1/20

Clinical trials — most relevant to ACTR2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Biologic Correlative Taxotere/AC	PHASE2	COMPLETED
Interleukin-2 Treatment for Wiskott-Aldrich Syndrome	PHASE1	COMPLETED
Evaluating MED2005 & Nitrostat Bioavailability	PHASE1	COMPLETED
Evaluation of the Safety and Efficacy of BBM-D101 to Treat Patients with Duchenne Muscular Dystrophy	EARLY_PHASE1	RECRUITING
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Evaluation of Vasopressin in the Vessels of Ovarian Neoplasms	nan	COMPLETED
Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development	nan	COMPLETED
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
Nuclear Myosin VI - a Therapeutic Target in Breast Cancer	nan	UNKNOWN
Stress and Treatment Response in Puerto Rican Children With Asthma	nan	COMPLETED
The Cognitive Resilience Study	nan	COMPLETED
Effect of Exercise on the Human Skeletal Muscle Phosphoproteome	nan	COMPLETED
Family Blood Pressure Program - GenNet Network	nan	COMPLETED
Magnetic Resonance Elastography (MRE) of Uterine Fibroids	nan	COMPLETED
Genetic Biomarkers for the Response to Anti-VEGF (Vascular Endothelial Growth Factor).Treatment in Wet Age-related Macular Degeneration (Wet ARMD)	nan	COMPLETED
Characterizing the Role of Pain Sensitivity in Acute to Persistent Low Back Pain	nan	COMPLETED
Family Blood Pressure Program - SAPPHIRe Network	nan	COMPLETED
Characteristics of Nondystrophic Myotonias	nan	COMPLETED
Chromosome 5Q Gene Variants and Asthma-Related Traits	nan	COMPLETED
Effect of Age on Glucose and Lipid Metabolism	nan	COMPLETED
EMT in Peritoneal Dialysis Patients	nan	COMPLETED
Optical and Biochemical Biomarkers in Early Pancreatic Cancer	nan	COMPLETED
CCM Italian Registry	nan	UNKNOWN
Family Blood Pressure Program - GENOA	nan	COMPLETED
Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS)	nan	RECRUITING
3D-Microscopic Muscle Architecture in Cerebral Palsy	nan	RECRUITING
GARM II: A Study on the Genetics of Age-related Maculopathy	nan	ACTIVE_NOT_RECRUITING
Natural History Study for Patients With Nemaline Myopathy in Belgium	nan	NOT_YET_RECRUITING
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others	nan	RECRUITING
The Synergistic Effects of AIH and FES in Persons With MS	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ACTR2 binder may also engage these)

Protein	Name	Similarity
P61161	—	1.000	P61161 →
A7MB62	—	1.000	A7MB62 →
Q7ZTP2	—	1.000	Q7ZTP2 →
Q7SXW6	—	1.000	Q7SXW6 →
Q5BL41	—	1.000	Q5BL41 →
Q5M7U6	—	1.000	Q5M7U6 →
Q5R4K0	—	1.000	Q5R4K0 →
P53488	—	1.000	P53488 →
Q7ZXV3	—	1.000	Q7ZXV3 →
O96621	—	1.000	O96621 →
Q56A35	—	1.000	Q56A35 →
Q61JZ2	—	1.000	Q61JZ2 →
P53487	—	0.999	P53487 →
P53489	—	0.999	P53489 →
P32381	—	0.998	P32381 →
P38696	—	0.997	P38696 →
P42023	—	0.997	P42023 →
P45888	—	0.997	P45888 →
P45889	—	0.996	P45889 →
Q9LSD6	—	0.995	Q9LSD6 →
Q6Z256	—	0.995	Q6Z256 →
Q54I79	—	0.995	Q54I79 →
Q9UUJ1	—	0.994	Q9UUJ1 →
P61164	—	0.992	P61164 →
P53503	—	0.992	P53503 →
A2YUL5	—	0.992	A2YUL5 →
Q4R6J9	—	0.992	Q4R6J9 →
P85515	—	0.990	P85515 →
P38673	—	0.990	P38673 →
P42025	—	0.990	P42025 →