ACTR3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Cobimetinib (SCHEMBL188704)	1.00	1/20
Cobimetinib (SCHEMBL189565)	1.00	1/20
Cobimetinib (SCHEMBL1488831)	1.00	1/20
Cobimetinib (SCHEMBL1488436)	0.98	1/20
Cobimetinib (SCHEMBL1489148)	0.98	1/20
SCHEMBL189480	0.95	1/20
SCHEMBL1488014	0.95	1/20
SCHEMBL1488833	0.95	1/20
SCHEMBL1488395	0.81	1/20
SCHEMBL1489096	0.81	1/20
SCHEMBL1488565	0.78	1/20
SCHEMBL1488306	0.77	1/20
SCHEMBL1488502	0.77	1/20
Acetic Acid (SCHEMBL1488743)	0.76	1/20
SCHEMBL1488415	0.76	1/20
SCHEMBL1488655	0.73	1/20
SCHEMBL1488272	0.73	1/20
Acetic Acid (SCHEMBL1488785)	0.72	1/20
SCHEMBL1488524	0.72	1/20
SCHEMBL1488525	0.72	1/20

Clinical trials — most relevant to ACTR3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Biologic Correlative Taxotere/AC	PHASE2	COMPLETED
Interleukin-2 Treatment for Wiskott-Aldrich Syndrome	PHASE1	COMPLETED
Evaluating MED2005 & Nitrostat Bioavailability	PHASE1	COMPLETED
Nuclear Myosin VI - a Therapeutic Target in Breast Cancer	nan	UNKNOWN
Stress and Treatment Response in Puerto Rican Children With Asthma	nan	COMPLETED
Evaluation of Vasopressin in the Vessels of Ovarian Neoplasms	nan	COMPLETED
Family Blood Pressure Program - GenNet Network	nan	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
Heart Failure and a Preserved Ejection Fraction	nan	COMPLETED
Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development	nan	COMPLETED
The Cognitive Resilience Study	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Family Blood Pressure Program - HyperGEN	nan	COMPLETED
Effect of Age on Glucose and Lipid Metabolism	nan	COMPLETED
Chromosome 5Q Gene Variants and Asthma-Related Traits	nan	COMPLETED
Genetic Biomarkers for the Response to Anti-VEGF (Vascular Endothelial Growth Factor).Treatment in Wet Age-related Macular Degeneration (Wet ARMD)	nan	COMPLETED
Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS)	nan	RECRUITING
Characterizing the Role of Pain Sensitivity in Acute to Persistent Low Back Pain	nan	COMPLETED
Family Blood Pressure Program - SAPPHIRe Network	nan	COMPLETED
Family Blood Pressure Program - GENOA	nan	COMPLETED
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing	nan	COMPLETED
Autophagy Bladder Cancer	nan	UNKNOWN
Prognostic Value of Protein IMP3 Expression in Cervical Cancer	nan	COMPLETED
Role of IMP3 Expression in Colorectal Carcinoma: An Immunohistochemical Study	nan	UNKNOWN
Effect of Exercise on the Human Skeletal Muscle Phosphoproteome	nan	COMPLETED
Natural History Study for Patients With Nemaline Myopathy in Belgium	nan	NOT_YET_RECRUITING
Study of the Pathophysiological Mechanisms Involved in Bleeding Events	nan	COMPLETED
Cardiopulmonary and Right Ventricular Function in Health and Disease	nan	UNKNOWN
Novel Biomarkers in the Neoplastic Progression of Barrett's Esophagus	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ACTR3 binder may also engage these)

Protein	Name	Similarity
Q99JY9	—	1.000	Q99JY9 →
Q5R8R1	—	1.000	Q5R8R1 →
Q4V7C7	—	1.000	Q4V7C7 →
P61157	—	1.000	P61157 →
Q90WD0	—	1.000	Q90WD0 →
O73723	—	1.000	O73723 →
A0A1L8EV45	—	1.000	A0A1L8EV45 →
Q801P7	—	0.995	Q801P7 →
Q641P0	—	0.986	Q641P0 →
Q9P1U1	—	0.986	Q9P1U1 →
F1QGW6	—	0.914	F1QGW6 →
P23330	—	0.910	P23330 →
Q5ZMS3	—	0.909	Q5ZMS3 →
Q2KHU8	—	0.909	Q2KHU8 →
Q5R797	—	0.909	Q5R797 →
F6RQL9	—	0.908	F6RQL9 →
Q05B83	—	0.908	Q05B83 →
P81795	—	0.908	P81795 →
MTAP	S-methyl-5'-thioadenosine phosphorylase	0.908	landscape →
P41091	—	0.907	P41091 →
PRKG1	cGMP-dependent protein kinase 1	0.906	landscape →
Q9Z0N1	—	0.906	Q9Z0N1 →
P20461	—	0.906	P20461 →
P00516	—	0.905	P00516 →
P53033	—	0.905	P53033 →
Q32KM1	—	0.905	Q32KM1 →
P23258	—	0.905	P23258 →
RFC2	Replication factor C subunit 2	0.904	landscape →
Q0VCD2	—	0.904	Q0VCD2 →
P0C605	—	0.901	P0C605 →