Sugi Predict

Sugi Predict / Targets / AGER

AGER

Advanced glycosylation end product-specific receptor · Q15109 · AGER on Sugi Atlas →

14,373 patent compounds predicted against AGER, 7,876 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1283031 SCHEMBL1283031 0.66 19/20
SCHEMBL1283369 SCHEMBL1283369 0.66 19/20
SCHEMBL1282251 SCHEMBL1282251 0.67 18/20
SCHEMBL1283052 SCHEMBL1283052 0.77 17/20
SCHEMBL1283307 SCHEMBL1283307 0.52 17/20
SCHEMBL1283512 SCHEMBL1283512 0.75 16/20
SCHEMBL1283446 SCHEMBL1283446 0.69 16/20
SCHEMBL1283406 SCHEMBL1283406 0.78 15/20
SCHEMBL1282798 SCHEMBL1282798 0.69 15/20
Azeliragon Azeliragon (SCHEMBL1142599) 1.00 14/20
SCHEMBL1283514 SCHEMBL1283514 1.00 14/20
SCHEMBL1283452 SCHEMBL1283452 0.82 14/20
SCHEMBL1283025 SCHEMBL1283025 0.77 14/20
SCHEMBL1283341 SCHEMBL1283341 0.75 14/20
SCHEMBL1283292 SCHEMBL1283292 0.57 14/20
SCHEMBL1283680 SCHEMBL1283680 0.85 13/20
SCHEMBL1283137 SCHEMBL1283137 0.73 13/20
SCHEMBL1283572 SCHEMBL1283572 0.69 13/20
SCHEMBL1283418 SCHEMBL1283418 0.68 13/20
SCHEMBL1283662 SCHEMBL1283662 0.67 13/20

Clinical trials — most relevant to AGER by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus PHASE4UNKNOWN
Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study) PHASE4COMPLETED
The Effects of Sevelamer Carbonate on Diabetic Nephropathy PHASE2COMPLETED
Safety and Efficacy Study of Pyridorin in Patients With Nephropathy Due to Type 2 Diabetes PHASE2COMPLETED
The Effect of Exercise and Alagebrium on the Diastolic Function of the Heart PHASE2COMPLETED
Effect of Sevelamer Carbonate on Oxidative Stress in Patients With Diabetic Nephropathy PHASE1COMPLETED
NAC Treatment and Outcomes in Patients With Advanced Atherosclerosis and DM PHASE1WITHDRAWN
Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity EARLY_PHASE1COMPLETED
Benfotiamine Effect on Advanced Glycation End Products(AGEs) and Soluble Receptor for AGEs(sRAGE) in Diabetes Mellitus. nanCOMPLETED
Exercise and the Receptor for Advanced Glycation End Products (RAGE) nanCOMPLETED
Soluble Receptors for Advanced Glycation End-Products and PCI nanUNKNOWN
Toxins Removal and Inflammatory State modulAtion During Online Hemodiafiltration: Comparison of Two Different Dialyzers nanUNKNOWN
Effect of Low-Glycemic Index Mediterranean Diet on AGEs nanCOMPLETED
Glycoxidation, Arterial Biomechanics, and Target Organ Damage nanRECRUITING
Effects of a Dietary Supplement on Collagen Production and Evaluation of Its Regenerative and Anti-Ageing Propertiess nanCOMPLETED
TCF7L2 Gene Polymorphism and AGEs in Diabetic Nephropathy nanUNKNOWN
Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients nanCOMPLETED
Impact of Muscle and Tendon Dysfunction in People With Type 2 Diabetes Mellitus nanUNKNOWN
Soluble Forms and Ligands of RAGE in ALI/ARDS (SoLiRAGE). nanCOMPLETED
The Relationship of RAGE Gene Polymorphism With Type I Diabetes in Egyptian Patients nanCOMPLETED
A Role for RAGE/TXNIP/Inflammasome Axis in Alveolar Macrophage Activation During ARDS (RIAMA): a Proof-of-concept Clinical Study nanCOMPLETED
DPP-IV Inhibitors Underlying Mechanism of Cancer in Diabetic Patients nanUNKNOWN
MD2, Cystatin C and DNA Methylation Tags as Serum Biomarkers for POCD. nanUNKNOWN
AGE and CALLY Index in Familial Mediterranean Fever nanNOT_YET_RECRUITING
Pilot Study of a Dietary Intervention Based Upon Advanced Glycation End Products nanCOMPLETED
Effects of Cardiac Rehabilitation on High Mobility Group Box-1 Levels After Acute Myocardial Infarction nanCOMPLETED
The Effects of Restricted Dietary of AGEs on the Glycemic Control, Oxidative Stress and Inflammation nanCOMPLETED
Advanced Glycation End Products and Dietary Intervention in Polycystic Ovary Patients nanUNKNOWN
Effects of a High-CML Diet on Absorption and Excretion Levels in Healthy Adults nanCOMPLETED
Effect of Oral L-arginine 3.32 g a Day on Oxidative Stress Influencing Beta Cell Function and Insulin Resistance. nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a AGER binder may also engage these)

ProteinNameSimilarity
Q62151 — 1.000 Q62151 →
Q28173 — 1.000 Q28173 →
Q63495 — 0.998 Q63495 →
D3YX43 — 0.992 D3YX43 →
Q5TJE4 — 0.989 Q5TJE4 →
Q5BK54 — 0.989 Q5BK54 →
Q86VR7 — 0.988 Q86VR7 →
O70394 — 0.987 O70394 →
P43121 — 0.986 P43121 →
A0A140LHF2 — 0.986 A0A140LHF2 →
O00241 — 0.986 O00241 →
Q9P0V8 — 0.986 Q9P0V8 →
P01877 — 0.986 P01877 →
O14931 — 0.985 O14931 →
O15533 — 0.985 O15533 →
Q9NPY3 — 0.985 Q9NPY3 →
D3YZF7 — 0.985 D3YZF7 →
P61484 — 0.985 P61484 →
Q61790 — 0.984 Q61790 →
P01880 — 0.984 P01880 →
Q8R2Y2 — 0.984 Q8R2Y2 →
Q9EPF2 — 0.983 Q9EPF2 →
P01876 — 0.983 P01876 →
P26952 — 0.983 P26952 →
Q9P1W8 — 0.982 Q9P1W8 →
Q9D3G2 — 0.982 Q9D3G2 →
Q9R233 — 0.982 Q9R233 →
Q5NKT8 — 0.982 Q5NKT8 →
O70540 — 0.982 O70540 →
Q6AYD4 — 0.982 Q6AYD4 →