AQP1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4219176	0.80	3/20
SCHEMBL4223622	0.79	3/20
SCHEMBL4220292	0.79	3/20
SCHEMBL4224838	0.79	3/20
SCHEMBL4224840	0.79	3/20
SCHEMBL4222532	0.78	3/20
SCHEMBL4222449	0.78	3/20
SCHEMBL4225189	0.77	3/20
SCHEMBL4222332	0.76	3/20
SCHEMBL4224721	0.74	3/20
SCHEMBL4224465	0.73	3/20
SCHEMBL4220698	0.73	3/20
SCHEMBL4220558	0.72	3/20
SCHEMBL4220568	0.72	3/20
SCHEMBL4223679	0.72	3/20
SCHEMBL4224942	0.72	3/20
SCHEMBL4220492	0.71	3/20
SCHEMBL4220265	0.69	3/20
SCHEMBL4219883	0.69	3/20
SCHEMBL4219199	0.67	3/20

Clinical trials — most relevant to AQP1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effect of Indomethacin in Monosymptomatic Enuresis Nocturnal	PHASE4	COMPLETED
Urinary Aquaporine 2 in Patients With Syndrome of Inappropriate ADH-secretion Caused by Treatment With Antiepileptic Medicine	PHASE4	WITHDRAWN
High-protein and High-carbohydrate Diets' Effect on Urinary Concentrating Ability	PHASE4	COMPLETED
Reduction of Edema With a Specialized Cocktail for Ultra-early Management in Intracerebral Hemorrhage	PHASE3	NOT_YET_RECRUITING
Secretin in Ex-situ Liver Perfusion	PHASE1/PHASE2	ENROLLING_BY_INVITATION
Study of Stroke Related Edema Treatments	PHASE2	WITHDRAWN
The Role of Vasopressin Antagonism on Renal Sodium Handling	PHASE1	COMPLETED
Conivaptan for the Reduction of Cerebral Edema in Intracerebral Hemorrhage- A Safety and Tolerability Study	PHASE1	COMPLETED
Phase 1 Study to Assess AER-271	PHASE1	COMPLETED
The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Healthy Humans.	nan	COMPLETED
Effect of Statin Treatment on Urinary AQP2 (uAQP2/01)	nan	COMPLETED
Asymptomatic Bacteriuria, Hyponatremia and Geri-atric Syndrome	nan	COMPLETED
Efficacy of a Water Intervention in Institutionalized Aged Population.	nan	COMPLETED
The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Essential Hypertension	nan	COMPLETED
Neuroimaging Risk of Postoperative Delirium	nan	UNKNOWN
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension	nan	UNKNOWN
Preoperative Prediction of of Thymic Epithelial Tumors by Diffusion-Weighted MR Imaging	nan	UNKNOWN
Nocturnal Blood Pressure and Hypertension - Central and Peripheral 24-h Blood Pressure.	nan	UNKNOWN
Effect of Hypertonic Sodium Chloride on Urinary Biomarkers in Healthy Subjects and Patients With Chronic Kidney Disease	nan	COMPLETED
Fluid Balance, Hormones and Urine Proteomics in Nephrotic Syndrome in Childhood	nan	COMPLETED
The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Autosomal Dominant Polycystic Kidney Disease	nan	COMPLETED
Urinary Aquaporin 2 and Expression of the NPHS2 Gene in Adults Suffering From Nephrotic Syndrome	nan	COMPLETED
The Effect of Thiazide, Amiloride and Hypertonic Saline on Urinary Biomarkers in Healthy Subjects	nan	COMPLETED
non_invasive_aICP_Tumor	nan	COMPLETED
Effect of a Specific Aquaporin-1 Inhibitor on Vascular Oxidative Stress in Healthy Volunteers	nan	COMPLETED
Imaging - Clinical Evaluation of Altered Nervous System Drainage	nan	UNKNOWN
Study of Genotype and Phenotype Expression in Congenital Nephrogenic Diabetes Insipidus	nan	COMPLETED
Monoclonal Antibody-Based Therapies for AQP4-Positive NMOSD	nan	RECRUITING
Hypotonic Hyponatremia: Criteria for the Correct Classification of Its Etiology and of Patient Volume Status	nan	COMPLETED
Evaluation of Volume and Electrolyte Balance in Hyponatremia Treatment - a Prospective Observational Trial	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a AQP1 binder may also engage these)

Protein	Name	Similarity
P29975	—	1.000	P29975 →
Q5R819	—	1.000	Q5R819 →
P47865	—	1.000	P47865 →
Q9N2J4	—	1.000	Q9N2J4 →
Q02013	—	1.000	Q02013 →
Q6PQZ1	—	1.000	Q6PQZ1 →
P56401	—	1.000	P56401 →
P50501	—	0.999	P50501 →
Q23808	—	0.998	Q23808 →
G5CTG2	—	0.996	G5CTG2 →
Q9WTY0	—	0.994	Q9WTY0 →
Q25074	—	0.993	Q25074 →
P55064	—	0.990	P55064 →
Q9V5Z7	—	0.990	Q9V5Z7 →
P56627	—	0.990	P56627 →
Q866S3	—	0.990	Q866S3 →
P47864	—	0.989	P47864 →
O77750	—	0.989	O77750 →
Q9WTY4	—	0.989	Q9WTY4 →
A8W649	—	0.989	A8W649 →
Q8LFP7	—	0.989	Q8LFP7 →
Q923J4	—	0.988	Q923J4 →
P23958	—	0.988	P23958 →
P55088	—	0.988	P55088 →
Q9ATL5	—	0.988	Q9ATL5 →
Q06019	—	0.988	Q06019 →
P47863	—	0.988	P47863 →
Q40746	—	0.988	Q40746 →
Q5I4F9	—	0.988	Q5I4F9 →
Q9ZVX8	—	0.988	Q9ZVX8 →