ARFGEF1

Brefeldin A-inhibited guanine nucleotide-exchange protein 1 · Q9Y6D6 · ARFGEF1 on Sugi Atlas →

0 patent compounds predicted against ARFGEF1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to ARFGEF1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma PHASE1/PHASE2RECRUITING
Reverse Transcriptase Inhibitors in AGS PHASE2COMPLETED
FOLFOX/Bevacizumab/Hydroxychloroquine (HCQ) in Colorectal Cancer PHASE1/PHASE2COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Interleukin-2 Treatment for Wiskott-Aldrich Syndrome PHASE1COMPLETED
FAK Inhibitor in Patients With Advanced Solid Tumors PHASE1NOT_YET_RECRUITING
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D) EARLY_PHASE1COMPLETED
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Thrombin Regulated Platelet Activation nanCOMPLETED
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients nanNOT_YET_RECRUITING
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise nanCOMPLETED
Hepatic Substrate Flux Rates in Type 2 Diabetes nanACTIVE_NOT_RECRUITING
Study of Proteins in Head and Neck Cancer Cells nanCOMPLETED
Genetic Analysis of Gray Platelet Syndrome nanCOMPLETED
Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders nanUNKNOWN
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Autophagy Bladder Cancer nanUNKNOWN
Identification of a New Gene Involved in Hereditary Lipodystrophy nanCOMPLETED
Value of MicroRNA30a in Philadelphia Positive Leukemic Patients nanUNKNOWN
NCF Gene & TNFSF4 in SLE Patients nanUNKNOWN
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
The Roles of Neutrophil Elastase in Lung Cancer nanUNKNOWN
Immune Cell Response to Stimuli nanRECRUITING
FGL2/Fibroleukin and Hepatitis C Virus Recurrence Post Liver Transplantation nanUNKNOWN
Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ARFGEF1 binder may also engage these)

ProteinNameSimilarity
D4A631 1.000 D4A631 →
O46382 1.000 O46382 →
G3X9K3 1.000 G3X9K3 →
Q9Y6D5 1.000 Q9Y6D5 →
Q7TSU1 0.994 Q7TSU1 →
A2A5R2 0.994 A2A5R2 →
F4JN05 0.992 F4JN05 →
G5EGS5 0.990 G5EGS5 →
Q8RW96 0.988 Q8RW96 →
F4IXW2 0.987 F4IXW2 →
O94915 0.986 O94915 →
Q9LU89 0.986 Q9LU89 →
Q9MAU3 0.985 Q9MAU3 →
Q9VFS5 0.985 Q9VFS5 →
Q923U0 0.984 Q923U0 →
Q9SV41 0.984 Q9SV41 →
E9PUQ8 0.984 E9PUQ8 →
PPP4R3A Serine/threonine-protein phosphatase 4 regulatory subunit 3A 0.984 landscape →
PPP2R5D Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform 0.984 landscape →
Q66L58 0.984 Q66L58 →
Q6P2K6 0.984 Q6P2K6 →
Q9Y4G8 0.984 Q9Y4G8 →
Q28653 0.984 Q28653 →
Q8R310 0.984 Q8R310 →
Q86XP1 0.983 Q86XP1 →
Q29L43 0.983 Q29L43 →
Q8CHG7 0.983 Q8CHG7 →
Q6NXC0 0.983 Q6NXC0 →
Q9VLT1 0.983 Q9VLT1 →
A2VE70 0.983 A2VE70 →