Sugi Predict

Sugi Predict / Targets / ARHGEF1

ARHGEF1

Rho guanine nucleotide exchange factor 1 · Q92888 · ARHGEF1 on Sugi Atlas →

0 patent compounds predicted against ARHGEF1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to ARHGEF1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study PHASE4COMPLETED
CB-PRP in Retinitis Pigmentosa and Dry Age-related Macular Degeneration PHASE3COMPLETED
Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC) PHASE2COMPLETED
Safety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) Patients PHASE1/PHASE2COMPLETED
Interleukin-2 Treatment for Wiskott-Aldrich Syndrome PHASE1COMPLETED
FAK Inhibitor in Patients With Advanced Solid Tumors PHASE1NOT_YET_RECRUITING
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma nanRECRUITING
NCF Gene & TNFSF4 in SLE Patients nanUNKNOWN
Prospective Validation of a DNA Damage Repair-Hippo Pathway Signature in Patients With Advanced Gastric Cancer nanUNKNOWN
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Identification of an Asthma Susceptibility Gene on 3P nanCOMPLETED
Thrombin Regulated Platelet Activation nanCOMPLETED
Genetic Analysis of Familial Cases of Premature Ovarian Failure nanCOMPLETED
Role of Polymorphisms in the IL-1 Gene Cluster nanCOMPLETED
Safety and Efficacy of Combination Acthar Gel and Tacrolimus in the Treatment of Steroid Resistant Nephrotic Syndrome nanSUSPENDED
Diet Intervention and GEnetic STudy (DIGEST-Pilot) nanUNKNOWN
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Gene Analysis of Parkinson's Disease nanCOMPLETED
Chromosome 5Q Gene Variants and Asthma-Related Traits nanCOMPLETED
Parkinson's Families Project nanRECRUITING
Signs and Symptoms Associated With Molecular Defects in Genetically Inherited Heart Disease nanCOMPLETED
Molecular Markers of Human Sperm Function nanWITHDRAWN
Genetic Biomarkers for the Response to Anti-VEGF (Vascular Endothelial Growth Factor).Treatment in Wet Age-related Macular Degeneration (Wet ARMD) nanCOMPLETED
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve nanUNKNOWN
Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations nanWITHDRAWN
Genetic Epidemiology of Asthma in Costa Rica nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ARHGEF1 binder may also engage these)

ProteinNameSimilarity
Q9Z1I6 — 1.000 Q9Z1I6 →
Q61210 — 1.000 Q61210 →
O75064 — 0.993 O75064 →
Q3KR16 — 0.993 Q3KR16 →
Q5RB40 — 0.992 Q5RB40 →
Q6ZSZ5 — 0.992 Q6ZSZ5 →
P0C6P5 — 0.992 P0C6P5 →
Q15027 — 0.992 Q15027 →
Q8WWN8 — 0.991 Q8WWN8 →
Q96C34 — 0.991 Q96C34 →
Q80XS6 — 0.990 Q80XS6 →
Q9D684 — 0.990 Q9D684 →
Q9H6S3 — 0.990 Q9H6S3 →
Q5RC07 — 0.990 Q5RC07 →
NR1H2 Oxysterols receptor LXR-beta 0.989 landscape →
Q9QZ28 — 0.989 Q9QZ28 →
A2AB59 — 0.989 A2AB59 →
Q5QJV7 — 0.988 Q5QJV7 →
A5PK26 — 0.988 A5PK26 →
O08774 — 0.988 O08774 →
Q68EF8 — 0.988 Q68EF8 →
Q86YV0 — 0.988 Q86YV0 →
A6QQ91 — 0.988 A6QQ91 →
Q8R0J1 — 0.988 Q8R0J1 →
Q6ZUM4 — 0.988 Q6ZUM4 →
Q9NQC1 — 0.988 Q9NQC1 →
Q3TBD2 — 0.988 Q3TBD2 →
Q92619 — 0.988 Q92619 →
Q96FS4 — 0.987 Q96FS4 →
Q8WYP3 — 0.987 Q8WYP3 →