ASS1

Argininosuccinate synthase · P00966 · ASS1 on Sugi Atlas →

0 patent compounds predicted against ASS1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to ASS1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
L-arginine Treatment in Mild Hypertension PHASE4UNKNOWN
L-Arginine in Pre-Eclampsia PHASE3COMPLETED
Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trial PHASE3COMPLETED
Phase II Study of Sodium Phenylbutyrate, Sodium Benzoate, Sodium Phenylacetate, and Dietary Intervention for Urea Cycle Disorders PHASE2COMPLETED
A Phase I/II Open-label Safety and Efficacy Study of LNP.UCD.ABE in Patients With Urea Cycle Disorders. PHASE1/PHASE2NOT_YET_RECRUITING
Arginine and Buphenyl in Patients With Argininosuccinic Aciduria (ASA), a Urea Cycle Disorder PHASE2COMPLETED
Does Heme Oxygenase-1 Induction Ameliorate Cardiac Injury After Myocardial Infarction? PHASE1/PHASE2COMPLETED
Increasing Ureagenesis in Inborn Errors of Metabolism With N-Carbamylglutamate PHASE2WITHDRAWN
Intravenous L-Citrulline Influence on the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure in Patients With COVID-19 PHASE2COMPLETED
Heme Arginate in Cardiac Surgery Patients PHASE2COMPLETED
Ph 1 Study of ADI PEG 20 in Pediatric Subjects Who Are Argininosuccinate Synthetase (ASS) Deficient PHASE1COMPLETED
Effects of Heme Arginate in Healthy Male Subjects PHASE1COMPLETED
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD nanCOMPLETED
Study in Healthy Subjects, Patients With Urea Cycle Disorders (UCD) and Carriers of UCD Mutations to Evaluate Urea Cycle Function nanCOMPLETED
Systemic Biomarkers of Brain Injury From Hyperammonemia nanRECRUITING
Longitudinal Study of Urea Cycle Disorders nanRECRUITING
Multi-omics Study in Citrin Deficiency nanACTIVE_NOT_RECRUITING
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD nanUNKNOWN
PCORI Urea Cycle Disorder Study nanCOMPLETED
Proof of Concept Creatine Supplementation for Homocystinuria Study nanACTIVE_NOT_RECRUITING
Clinical and Laboratory Study of Methylmalonic Acidemia nanRECRUITING
Liver Disease in Urea Cycle Disorders nanACTIVE_NOT_RECRUITING
Effect of L-Citrulline Supplementation on Arginase Activity and Vascular Function in Diabetes nanUNKNOWN
Effect of the Amino Acid L-arginine on Perioperative Cardio-vascular Risk in Non-selected Patients nanCOMPLETED
Identification of Acute Intermittent Porphyria Modifying Genes nanRECRUITING
Effect of Arginine and Glutamine on Radiation-induced Oral Mucositis: a Trible Blinded Randomized Controlled Clinical Trial nanCOMPLETED
A Clinical Study of Glycerol Phenylbutyrate in Chinese Patients With Urea Cycle Disorders nanRECRUITING
L-Arginine, Symmetrical and Asymmetrical Dimethylarginine (SDMA/ADMA) in Acute Kidney Injury (AKI) nanCOMPLETED
L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE) nanRECRUITING
Effect of Nutritional Supplementation and Pulmonary Rehabilitation on the Clinical Status of HF and COPD nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a ASS1 binder may also engage these)

ProteinNameSimilarity
P14568 1.000 P14568 →
Q66I24 1.000 Q66I24 →
Q7ZWM4 1.000 Q7ZWM4 →
P16460 1.000 P16460 →
Q5M8Z6 1.000 Q5M8Z6 →
P09034 1.000 P09034 →
Q5ZJ23 1.000 Q5ZJ23 →
B1LAP4 1.000 B1LAP4 →
O97069 1.000 O97069 →
Q24ZG8 1.000 Q24ZG8 →
Q3Z727 1.000 Q3Z727 →
Q8ELT8 1.000 Q8ELT8 →
B9E0B1 1.000 B9E0B1 →
A6Q3P9 1.000 A6Q3P9 →
Q2K3B7 1.000 Q2K3B7 →
Q9X2A1 1.000 Q9X2A1 →
B9M374 1.000 B9M374 →
Q7PR38 1.000 Q7PR38 →
Q6AR59 1.000 Q6AR59 →
Q8UC31 1.000 Q8UC31 →
A1VZ24 1.000 A1VZ24 →
P61527 1.000 P61527 →
A0RP84 1.000 A0RP84 →
Q2RG67 1.000 Q2RG67 →
A5N6U2 1.000 A5N6U2 →
B0S9J6 1.000 B0S9J6 →
B4S9U5 1.000 B4S9U5 →
P61524 1.000 P61524 →
Q5WED8 1.000 Q5WED8 →
Q67KE1 1.000 Q67KE1 →