BPGM — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL24347958	1.00	6/20
SCHEMBL24348018	0.87	6/20
SCHEMBL24348463	0.77	6/20
SCHEMBL24348922	0.77	6/20
SCHEMBL24347957	0.75	6/20
SCHEMBL24349273	0.75	6/20
SCHEMBL30445506	0.75	6/20
SCHEMBL24347960	0.75	6/20
SCHEMBL24347961	0.75	6/20
SCHEMBL30445133	0.75	6/20
SCHEMBL30445767	0.75	6/20
SCHEMBL24348422	0.72	6/20
SCHEMBL24349262	0.72	6/20
SCHEMBL24348432	0.70	6/20
SCHEMBL24348975	0.68	6/20
SCHEMBL24271961	0.67	6/20
SCHEMBL24349029	0.65	6/20
SCHEMBL26704333	0.64	6/20
SCHEMBL24348022	0.64	6/20
SCHEMBL24348974	0.64	6/20

Clinical trials — most relevant to BPGM by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study of KRN23 in Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia	PHASE3	COMPLETED
Alendronate Versus Denosumab in Kidney Transplant Patients	PHASE2/PHASE3	COMPLETED
24-Week Study to Assess the PD, Safety, Tolerability, and PK of GLM101 in Participants With PMM2-CDG	PHASE2	COMPLETED
Open-Label Extension Study to Assess GLM101 in PMM2-CDG Patients	PHASE2	ENROLLING_BY_INVITATION
Exome Sequencing for Atypical Femoral Fractures	nan	COMPLETED
Characterisation of Adult-Onset Hypophosphatasia	nan	COMPLETED
Institution of an Italian Multicenter Database of Patients Affected by Diseases of Phosphate Metabolism	nan	NOT_YET_RECRUITING
Studying Phosphorus Metabolism	nan	COMPLETED
Use of Ibandronate in Diabetic Patients	nan	COMPLETED
Prospective, Longitudinal, Observational Registry of Adult Patients With Hypophosphatasia (REG-HYPO)	nan	RECRUITING
Pathophysiology of Paget's Disease of Bone	nan	COMPLETED
Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders	nan	UNKNOWN
Large-scale COVID-19 Population Screening	nan	UNKNOWN
A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders	nan	RECRUITING
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte	nan	COMPLETED
Unraveling Genetics of HypoPhosPhatasia (HPP Genetics)	nan	COMPLETED
Clinical and Laboratory Study of Methylmalonic Acidemia	nan	RECRUITING
GSD VI and GSD IX Natural History	nan	RECRUITING
MyRareDiet A Novel Diet Tracking Tool	nan	NOT_YET_RECRUITING
Study to Identify the Genetic Variations Associated With Phantom Limb Pain	nan	COMPLETED
Clinical and Molecular Studies in Families With Inherited Eye Disease	nan	RECRUITING
Identification and Characterization of Monogenic Diabetes	nan	COMPLETED
Biomarkers of Bone Resorption in Metastatic Prostate Cancer	nan	COMPLETED
Effect of Local Subperiosteal Zoledronic Acid Injection on the Survival of Orthodontic Miniscrews	nan	COMPLETED
Glycosylation in Patients With Galactosaemia	nan	COMPLETED
Natural History, Pathogenesis and Outcome of Melorheostosis A Rare Osteosclerotic Disease	nan	RECRUITING
Texture Analysis for Postmenopausal Osteoporosis	nan	COMPLETED
Catheterization to Locate Mesenchymal Tumors in Patients With Tumor-Induced Osteomalacia or Oncogenic Osteomalacia	nan	COMPLETED
Observational Study of Acute Intermittent Porphyria Patients	nan	COMPLETED
Tamoxifen Pharmacogenetics in Asian Breast Cancer Women	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a BPGM binder may also engage these)

Protein	Name	Similarity
Q4R6L7	—	1.000	Q4R6L7 →
P15327	—	1.000	P15327 →
P07952	—	1.000	P07952 →
Q3T014	—	1.000	Q3T014 →
Q2Y9Z7	—	0.994	Q2Y9Z7 →
B7H7P4	—	0.992	B7H7P4 →
C1EUQ5	—	0.992	C1EUQ5 →
Q737X5	—	0.991	Q737X5 →
B7IX37	—	0.991	B7IX37 →
Q3JBA8	—	0.991	Q3JBA8 →
A0RE96	—	0.990	A0RE96 →
A9VFW9	—	0.990	A9VFW9 →
B9J102	—	0.990	B9J102 →
B7HS46	—	0.990	B7HS46 →
B3DZZ7	—	0.989	B3DZZ7 →
Q6HIL9	—	0.989	Q6HIL9 →
Q81DD2	—	0.988	Q81DD2 →
Q8A8R2	—	0.988	Q8A8R2 →
B2RHB7	—	0.988	B2RHB7 →
Q63B92	—	0.987	Q63B92 →
Q6KSL4	—	0.987	Q6KSL4 →
Q732Z5	—	0.987	Q732Z5 →
Q7VL28	—	0.987	Q7VL28 →
A6L9K8	—	0.987	A6L9K8 →
Q64R85	—	0.987	Q64R85 →
Q5LAT7	—	0.987	Q5LAT7 →
Q4L8T0	—	0.987	Q4L8T0 →
B4U616	—	0.987	B4U616 →
Q82GB8	—	0.987	Q82GB8 →
C3PAW8	—	0.986	C3PAW8 →