BRSK2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3385790	0.73	2/20
SCHEMBL3385788	0.70	2/20
SCHEMBL3389336	0.69	2/20
SCHEMBL3384531	0.68	2/20
SCHEMBL3388562	0.67	2/20
SCHEMBL3388988	0.67	2/20
SCHEMBL3384528	0.65	2/20
Hydrochloric Acid (SCHEMBL3388881)	0.65	2/20
SCHEMBL3384222	0.64	2/20
SCHEMBL3386373	0.64	2/20
SCHEMBL3387955	0.64	2/20
SCHEMBL3386252	0.64	2/20
SCHEMBL3389020	0.62	2/20
SCHEMBL3388099	0.60	2/20
Hydrochloric Acid (SCHEMBL3389146)	0.59	2/20
SCHEMBL3386205	0.57	2/20
SCHEMBL3387099	0.57	2/20
SCHEMBL3384265	0.56	2/20
SCHEMBL3384251	0.56	2/20
SCHEMBL3385005	0.54	2/20

Clinical trials — most relevant to BRSK2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism	PHASE4	COMPLETED
Salt Loading and Thiazide Intervention Study	PHASE4	COMPLETED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients	PHASE3	COMPLETED
Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients	PHASE3	ACTIVE_NOT_RECRUITING
Efficacy and Safety of 0.25% Timolol Gel in Healing Surgical Open Wounds	PHASE2/PHASE3	COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Ibrutinib, Obinutuzumab and Venetoclax for Patients With Chronic Lymphocytic Leukemia	PHASE2	COMPLETED
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction	PHASE2	ACTIVE_NOT_RECRUITING
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses	PHASE1	UNKNOWN
Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans	PHASE1	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Study of Metabolic Modifications in Children With Noonan Syndrome	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
Genetic Predictors of Lithium Response in Bipolar Disorder	nan	COMPLETED
Clinical, Genetic, and Epidemiologic Study of Children and Adults With RASopathies	nan	RECRUITING
NTRK 1,2,3 Rearrangements in Patients With Solid Tumors	nan	ACTIVE_NOT_RECRUITING
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Clinical Genetics Branch Eligibility Screening Survey	nan	NOT_YET_RECRUITING
Genes, Proteins, and Metabolites in Drug-resistant Epilepsy (DRE) Patients	nan	NOT_YET_RECRUITING
Identification of Novel Targetable Kinases in SR-a GvHD	nan	COMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Integrated Proteomic HPLC-ESI-MS Analysis of Salivary Peptides of Preterm Newborns: a Pilot Study	nan	COMPLETED
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants.	nan	UNKNOWN
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy)	nan	UNKNOWN
Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases	nan	UNKNOWN
Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists.	nan	RECRUITING
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction	nan	COMPLETED
Brain Tissue Integrity and Autonomic Function Alterations in Childhood OSA and ADHD, and After Adenotonsillectomy.	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a BRSK2 binder may also engage these)

Protein	Name	Similarity
Q69Z98	—	1.000	Q69Z98 →
Q5RJI5	—	1.000	Q5RJI5 →
B2DD29	—	0.999	B2DD29 →
BRSK1	Serine/threonine-protein kinase BRSK1	0.996	landscape →
Q28GW8	—	0.990	Q28GW8 →
Q61083	—	0.990	Q61083 →
Q8CIP4	—	0.990	Q8CIP4 →
Q61084	—	0.990	Q61084 →
E9PUQ8	—	0.989	E9PUQ8 →
Q68UT7	—	0.989	Q68UT7 →
MAP3K9	Mitogen-activated protein kinase kinase kinase 9	0.989	landscape →
MAP3K3	Mitogen-activated protein kinase kinase kinase 3	0.989	landscape →
Q91821	—	0.989	Q91821 →
F1QGZ6	—	0.988	F1QGZ6 →
Q60949	—	0.988	Q60949 →
Q03141	—	0.988	Q03141 →
MELK	Maternal embryonic leucine zipper kinase	0.988	landscape →
Q99KY4	—	0.987	Q99KY4 →
Q9QY01	—	0.987	Q9QY01 →
O08679	—	0.987	O08679 →
Q61846	—	0.987	Q61846 →
Q80U87	—	0.987	Q80U87 →
Q8VHF0	—	0.987	Q8VHF0 →
Q2I6J1	—	0.987	Q2I6J1 →
GAK	Cyclin-G-associated kinase	0.987	landscape →
U4PR86	—	0.987	U4PR86 →
Q8VBY2	—	0.987	Q8VBY2 →
Q8RXT4	—	0.987	Q8RXT4 →
Q8R0S2	—	0.987	Q8R0S2 →
P97874	—	0.987	P97874 →