BUB1B

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta · O60566 · BUB1B on Sugi Atlas →

1,985 patent compounds predicted against BUB1B, 1,847 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL265061 SCHEMBL265061 1.00 1/20
Ceritinib Ceritinib (SCHEMBL1014329) 1.00 1/20
Ceritinib Ceritinib (SCHEMBL9936675) 0.98 1/20
SCHEMBL1545837 SCHEMBL1545837 0.94 1/20
SCHEMBL1014579 SCHEMBL1014579 0.89 1/20
SCHEMBL12224983 SCHEMBL12224983 0.86 1/20
SCHEMBL271198 SCHEMBL271198 0.85 1/20
SCHEMBL263665 SCHEMBL263665 0.84 1/20
SCHEMBL1545350 SCHEMBL1545350 0.84 1/20
SCHEMBL1545942 SCHEMBL1545942 0.84 1/20
SCHEMBL270925 SCHEMBL270925 0.83 1/20
SCHEMBL263679 SCHEMBL263679 0.83 1/20
SCHEMBL265965 SCHEMBL265965 0.82 1/20
SCHEMBL1545695 SCHEMBL1545695 0.82 1/20
SCHEMBL1545696 SCHEMBL1545696 0.82 1/20
SCHEMBL1546327 SCHEMBL1546327 0.82 1/20
SCHEMBL12213859 SCHEMBL12213859 0.82 1/20
SCHEMBL270528 SCHEMBL270528 0.82 1/20
SCHEMBL266295 SCHEMBL266295 0.82 1/20
SCHEMBL12237713 SCHEMBL12237713 0.82 1/20

Clinical trials — most relevant to BUB1B by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Clinical and Pharmacoeconomic Assessment of CDK4/6 Inhibitors for Treatment of Breast Cancer in Egypt PHASE4COMPLETED
A Study of Azenosertib (ZN-c3) Versus Investigator's Choice Chemotherapy in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression PHASE3RECRUITING
Vinorelbine in Relapsed Platinum Resistant or Refractory C5 High Grade Serous, Endometrioid, or Undifferentiated Primary Peritoneum, Fallopian Tube or Ovarian Cancer PHASE2UNKNOWN
Cisplatin and Paclitaxel With or Without Everolimus in Treating Patients With Stage II or Stage III Breast Cancer PHASE2COMPLETED
Everolimus in CDK12-Deficient Metastatic Colorectal Cancer (EVER-RECODE) PHASE1/PHASE2NOT_YET_RECRUITING
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma PHASE1/PHASE2COMPLETED
I/II Phase Study Evaluating M1774 in Combination With Fulvestrant in HR+ and HER2- Advanced Breast Cancers PHASE1/PHASE2NOT_YET_RECRUITING
TQB3616 Capsules Combined With Abiraterone Acetate Plus Prednisone in Metastatic Castration-Resistant Prostate Cancer PHASE2UNKNOWN
A Phase 1/2 Trial SRA737 in Combination With Gemcitabine and Cisplatin or Gemcitabine Alone in Advanced Cancer Subjects PHASE1/PHASE2COMPLETED
Abemaciclib With or Without Atezolizumab for mCRPC PHASE2COMPLETED
TTFields and Chemotherapy in Metastatic Pancreatic Adenocarcinoma (mPDAC) PHASE1/PHASE2RECRUITING
Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors PHASE1/PHASE2COMPLETED
A Phase 1/2 Trial of SRA737 in Subjects With Advanced Cancer PHASE1/PHASE2COMPLETED
Everolimus in Treating Patients With Relapsed or Refractory Multiple Myeloma PHASE2COMPLETED
Phase I Study of Oral BAY 1217389 in Combination With Intravenous Paclitaxel PHASE1COMPLETED
AZD1775 for Advanced Solid Tumors PHASE1COMPLETED
Veliparib (ABT-888), an Oral PARP Inhibitor, and VX-970, an ATR Inhibitor, in Combination With Cisplatin in People With Refractory Solid Tumors PHASE1COMPLETED
Study of ABT-751 in Patients With Refractory Hematologic Malignancies PHASE1COMPLETED
Phase I Study to Assess the Safety, Pharmacokinetics, & Pharmacodynamics of GSK923295 in Subjects w/ Refractory Cancer PHASE1COMPLETED
Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas PHASE1COMPLETED
Aurora B/C Kinase Inhibitor GSK1070916A in Treating Patients With Advanced Solid Tumors PHASE1COMPLETED
A Clinical Study of TQB3824 in Subjects With Advanced Cancer PHASE1UNKNOWN
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck PHASE1COMPLETED
A Study of Investigational Drug CFI-402257 in Patients With Advanced Solid Tumors PHASE1COMPLETED
Wee1 Kinase Inhibitor AZD1775 and Combination Chemotherapy in Treating Children, Adolescents and Young Adults With Relapsed or Refractory Acute Myeloid Leukemia PHASE1WITHDRAWN
Tabectedin to Treat Children and Adolescents With Cancer PHASE1COMPLETED
Study of the Effect of Innate on the Inflammatory Response to Endotoxin nanRECRUITING
Phosphoproteomic Patterns as a Novel Biomarker for Aurora and Polo-like Kinase Inhibitors in Non-Small Cell Lung Cancer nanCOMPLETED
Better Delineation of CDK13 Related Phenotype and Epigenetic Signature. nanUNKNOWN
AURORA: Aiming to Understand the Molecular Aberrations in Metastatic Breast Cancer. nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a BUB1B binder may also engage these)

ProteinNameSimilarity
Q9Z1S0 0.998 Q9Z1S0 →
Q8BMD7 0.995 Q8BMD7 →
O08901 0.995 O08901 →
O22806 0.992 O22806 →
PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 0.991 landscape →
Q9C0F1 0.991 Q9C0F1 →
Q5R789 0.990 Q5R789 →
Q1LYM3 0.990 Q1LYM3 →
Q6DD45 0.990 Q6DD45 →
Q6DGB6 0.990 Q6DGB6 →
O59767 0.990 O59767 →
Q8TDB6 0.990 Q8TDB6 →
Q9FY74 0.990 Q9FY74 →
Q9DDT2 0.990 Q9DDT2 →
Q9NQW6 0.990 Q9NQW6 →
Q6IVY4 0.990 Q6IVY4 →
Q7T0S7 0.989 Q7T0S7 →
Q9LSP8 0.989 Q9LSP8 →
Q28E45 0.989 Q28E45 →
P58501 0.989 P58501 →
Q8NHQ8 0.989 Q8NHQ8 →
P35611 0.988 P35611 →
A1A4J7 0.988 A1A4J7 →
Q8BX57 0.988 Q8BX57 →
Q9LZZ7 0.988 Q9LZZ7 →
Q3T9Z9 0.988 Q3T9Z9 →
Q6NRK1 0.988 Q6NRK1 →
Q9CYA6 0.988 Q9CYA6 →
Q9Y2H2 0.988 Q9Y2H2 →
A8E7C5 0.988 A8E7C5 →