CDK5R1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Kenpaullone (SCHEMBL79889)	1.00	17/20
Purvalanol B (SCHEMBL27951)	1.00	14/20
Aloisine (SCHEMBL79714)	1.00	13/20
SCHEMBL102235	1.00	13/20
SCHEMBL102955	1.00	13/20
SCHEMBL102656	0.79	13/20
SCHEMBL102951	0.76	13/20
SCHEMBL102660	0.75	13/20
SCHEMBL102233	1.00	12/20
SCHEMBL103266	0.82	12/20
SCHEMBL102507	0.78	12/20
SCHEMBL102984	0.77	12/20
SCHEMBL102650	0.76	12/20
SCHEMBL102952	0.76	12/20
SCHEMBL103265	1.00	11/20
SCHEMBL102236	0.75	11/20
SCHEMBL102764	0.75	11/20
SCHEMBL102225	0.72	11/20
SCHEMBL102239	0.70	11/20
SCHEMBL102240	0.67	11/20

Clinical trials — most relevant to CDK5R1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical and Pharmacoeconomic Assessment of CDK4/6 Inhibitors for Treatment of Breast Cancer in Egypt	PHASE4	COMPLETED
Enhancing Effect on Tumour Apoptosis With the Use of Pentoxifylline in Patients With Hodgkin Lymphoma	PHASE4	UNKNOWN
A Phase 3 Study Comparing Dinaciclib Versus Ofatumumab in Patients With Refractory Chronic Lymphocytic Leukemia (P07714)	PHASE3	COMPLETED
Effect of Silymarin in Metastatic Colorectal Cancer Patients	PHASE3	UNKNOWN
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction	PHASE2	ACTIVE_NOT_RECRUITING
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
IST Neoadjuvant Abraxane in Newly Diagnosed Breast Cancer	PHASE2	UNKNOWN
Dinaciclib, Bortezomib, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma	PHASE1	COMPLETED
AZD1775 for Advanced Solid Tumors	PHASE1	COMPLETED
Combination Chemotherapy in Treating Patients With Refractory or Recurrent Solid Tumors	PHASE1	COMPLETED
TSL2109 Capsules in Advanced Solid Tumor Patients: Safety, Tolerability, PK and Preliminary Efficacy	PHASE1	RECRUITING
Regulation of Vitamin D Receptor (VDR),Calcium Sensing Receptor (CaSR), Cyclin D1,Ki67 and Proliferating Cell Nuclear Antigen (PCNA) in Primary Hyperparathyroidism	nan	UNKNOWN
Genetics of Prostate Cancer in Young Patients	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
Molecular Pathways Related to Short-term Fasting Response	nan	COMPLETED
Genetics of Recurrent Early Onset Major Depression	nan	COMPLETED
Implementing Patients´ Competence in Oral Breast Cancer Therapy	nan	UNKNOWN
Molecular Mechanisms Underlying Prostate Cancer Disparities	nan	COMPLETED
Characterization of At-risk Population for Pre-sacral Tumor in CURRARINO Syndrome	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
The Association Between Fever and CDKL5 Deficiency Disorder: a Nationwide Survey	nan	COMPLETED
Molecular Genetic Mechanisms of Infantile Epilepsies and the Impact of Genetic Diagnosis	nan	RECRUITING
Genetic Analysis of Familial Melanoma	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Brain Development Research Program	nan	UNKNOWN
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics	nan	UNKNOWN
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders	nan	COMPLETED
The Beneficial Effects of Pomegranate on Hearing of Patients Without Hemodialysis	nan	COMPLETED
Characterization of Microbiological and Genetic Features in Prostate Cancer and Their Association with Disease Stage	nan	ENROLLING_BY_INVITATION
Markers for Breast Cancer	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CDK5R1 binder may also engage these)

Protein	Name	Similarity
P61810	—	1.000	P61810 →
P61809	—	1.000	P61809 →
Q28199	—	1.000	Q28199 →
Q4KYY2	—	1.000	Q4KYY2 →
Q9H694	—	0.977	Q9H694 →
Q5RHD1	—	0.976	Q5RHD1 →
O54828	—	0.976	O54828 →
Q80TJ7	—	0.976	Q80TJ7 →
Q8BMA3	—	0.976	Q8BMA3 →
Q9XSW2	—	0.976	Q9XSW2 →
Q28C33	—	0.975	Q28C33 →
Q62925	—	0.975	Q62925 →
KAT2A	Histone acetyltransferase KAT2A	0.975	landscape →
Q6GQL0	—	0.975	Q6GQL0 →
Q63085	—	0.974	Q63085 →
Q8K4S7	—	0.974	Q8K4S7 →
O35926	—	0.974	O35926 →
Q68EF0	—	0.974	Q68EF0 →
B0KWC1	—	0.973	B0KWC1 →
Q8R5A6	—	0.973	Q8R5A6 →
A7UA95	—	0.973	A7UA95 →
Q9CXF4	—	0.973	Q9CXF4 →
Q9UPX8	—	0.973	Q9UPX8 →
Q6F6B3	—	0.973	Q6F6B3 →
P0CH95	—	0.973	P0CH95 →
Q6DN90	—	0.973	Q6DN90 →
Q9HCS5	—	0.972	Q9HCS5 →
Q62136	—	0.972	Q62136 →
O08561	—	0.972	O08561 →
P50241	—	0.972	P50241 →