CIB1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL16140622	0.63	5/20
SCHEMBL16128548	0.61	5/20
SCHEMBL16128641	0.61	5/20
SCHEMBL16128604	0.60	5/20
SCHEMBL16128689	0.59	5/20
SCHEMBL16128595	0.58	5/20
SCHEMBL16128584	0.58	5/20
SCHEMBL16128830	0.58	5/20
SCHEMBL16128385	0.57	5/20
SCHEMBL16128435	0.56	5/20
SCHEMBL16128396	0.56	5/20
SCHEMBL16128535	0.55	5/20
SCHEMBL16128540	0.55	5/20
SCHEMBL16140602	0.55	5/20
SCHEMBL16140521	0.54	5/20
SCHEMBL16140593	0.54	5/20
SCHEMBL16128793	0.53	5/20
SCHEMBL16140628	0.53	5/20
SCHEMBL16140645	0.53	5/20
SCHEMBL16140660	0.53	5/20

Clinical trials — most relevant to CIB1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma	PHASE2	RECRUITING
Effects of Maraviroc (MVC) on HIV-related Kaposi's Sarcoma (KS)	PHASE2	COMPLETED
Testing the Ability of JNJ-18038683 to Improve Cognition and Reduce Depressive Symptoms in Stable Bipolar Patients	PHASE2	COMPLETED
Safety/Biomarker Study of CNTO 95 and Avastin in Solid Tumors	PHASE1	COMPLETED
Evaluating MED2005 & Nitrostat Bioavailability	PHASE1	COMPLETED
Single Ascending-dose Study to Evaluate Safety, Tolerability, and PK of MYMD1 in Healthy Male Adult Subjects	PHASE1	COMPLETED
68Ga-BNOTA-PRGD2 PET/CT in Patients With Rheumatoid Arthritis	EARLY_PHASE1	UNKNOWN
Relationship of Gestational Age and Urine Concentration of S100B in Preterm and Term Infants in the First Week of Life	nan	COMPLETED
Urine Concentration of S100B in Extremely Premature Infants	nan	COMPLETED
Angiogenesis and Fibrosis in Aortic Stenosis	nan	COMPLETED
Angiogenesis and Fibrosis in Myocardial Infarction	nan	COMPLETED
Assessing Bone Calcium Content in Children With Kidney Disease Treated With Two Different Medicines	nan	UNKNOWN
Comparison of Two Methods to Diagnose Coronary Artery Disease	nan	COMPLETED
Joint Determinants of Bone Density and CVD Calcification	nan	COMPLETED
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy)	nan	UNKNOWN
Epidemiology of Coronary Artery Calcification	nan	COMPLETED
Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders	nan	UNKNOWN
Transcranial Magnetic Stimulation (TMS) Studies of Dystonia	nan	COMPLETED
S100A8 in Serum and Urine as a New Biomarker in Lupus Nephritis	nan	COMPLETED
Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations	nan	WITHDRAWN
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages	nan	COMPLETED
An Epidemiological Study of Subjects With Immune Thrombocytopenic Purpura to Evaluate the Relationship Between Platelet Counts, Endogenous Thrombopoietin Levels, Endogenous Anti-Thrombopoietin Antibodies, and Selected Autoimmune Markers	nan	COMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events	nan	COMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Sodium Channel Splicing in Heart Failure Trial	nan	COMPLETED
Serum Talin-1 and Cripto-1 in Colorectal Cancer	nan	NOT_YET_RECRUITING
Genetic Architecture of Chronic Inflammatory Demyelinating Polyradiculoneuropathy	nan	UNKNOWN
Signs and Symptoms Associated With Molecular Defects in Genetically Inherited Heart Disease	nan	COMPLETED
Familial Intracranial Aneurysm Study II	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CIB1 binder may also engage these)

Protein	Name	Similarity
B1A8Z2	—	1.000	B1A8Z2 →
Q17QE5	—	1.000	Q17QE5 →
Q9R010	—	1.000	Q9R010 →
Q9Z0F4	—	1.000	Q9Z0F4 →
C7A278	—	0.983	C7A278 →
A0PJX0	—	0.981	A0PJX0 →
Q9D9N5	—	0.978	Q9D9N5 →
Q6P8Y1	—	0.958	Q6P8Y1 →
P07090	—	0.956	P07090 →
A4IG32	—	0.956	A4IG32 →
DCUN1D5	DCN1-like protein 5	0.955	landscape →
Q3ZBY3	—	0.955	Q3ZBY3 →
P47728	—	0.955	P47728 →
CAPNS1	Calpain small subunit 1	0.955	landscape →
Q08331	—	0.954	Q08331 →
Q8WWF8	—	0.954	Q8WWF8 →
Q1RMX9	—	0.954	Q1RMX9 →
Q96L46	—	0.954	Q96L46 →
Q9D7J7	—	0.954	Q9D7J7 →
O88456	—	0.953	O88456 →
P22676	—	0.953	P22676 →
P06813	—	0.952	P06813 →
Q5RDF9	—	0.952	Q5RDF9 →
Q9JJ57	—	0.952	Q9JJ57 →
Q9CQ46	—	0.951	Q9CQ46 →
B1H2N3	—	0.951	B1H2N3 →
Q9CXV9	—	0.951	Q9CXV9 →
Q99MG9	—	0.949	Q99MG9 →
Q5PPL2	—	0.949	Q5PPL2 →
P13135	—	0.949	P13135 →