CLPP — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL748496	0.77	20/20
SCHEMBL746578	0.69	20/20
SCHEMBL747280	0.67	20/20
SCHEMBL745648	0.60	20/20
SCHEMBL745480	0.59	20/20
SCHEMBL746130	0.59	20/20
SCHEMBL748921	0.57	20/20
SCHEMBL748243	0.57	20/20
SCHEMBL745617	0.56	20/20
SCHEMBL747527	0.56	20/20
SCHEMBL747665	0.56	20/20
SCHEMBL748273	0.56	20/20
SCHEMBL744855	0.56	20/20
SCHEMBL744822	0.55	20/20
SCHEMBL745917	0.55	20/20
SCHEMBL746304	0.55	20/20
SCHEMBL746128	0.55	20/20
SCHEMBL745373	0.55	20/20
SCHEMBL748823	0.54	20/20
SCHEMBL744663	0.54	20/20

Clinical trials — most relevant to CLPP by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phlogenzym® in Patients With Acute Thrombophlebitis - Efficacy and Tolerance	PHASE3	COMPLETED
Comparative Clinical Study to Evaluate the Possible Efficacy and Safety of Oral N-Acetyl Cysteine Versus Rectal Diclofenac in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis	PHASE1/PHASE2	COMPLETED
A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis	PHASE1/PHASE2	COMPLETED
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy	PHASE2	COMPLETED
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
Arsenic Trioxide in Refractory Solid Tumors With Rescuable p53 Mutation	PHASE2	UNKNOWN
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors	PHASE1	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Disorders of the Acute Phase Response Following Trauma and Invasive Surgery	nan	ENROLLING_BY_INVITATION
Reduced Ventilator-Free Days and Bacterial Colonization of Sub-Glottic Secretions	nan	WITHDRAWN
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
A Study Providing Genetic Testing to Find Those Who May Have Primary Ciliary Dyskinesia for Potential Clinical Trials	nan	ACTIVE_NOT_RECRUITING
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract	nan	UNKNOWN
Probiotics and Systemic Inflammation in Patients With Metabolic Syndrome and High Cardiovascular Risk	nan	WITHDRAWN
Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients	nan	UNKNOWN
Role of Thromboelastography in Septic Shock	nan	COMPLETED
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Molecular Detection Of Efflux Pump and Virulence Factors Genes in Pseudomonas Aeruginosa	nan	UNKNOWN
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Sepsis-damaged Organs-double-markers Identification of Organ Failure Using Fluorescent Nanoparticle Tracking Analysis	nan	COMPLETED
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
Impact of CASP3 Gene in Chemoresistance	nan	NOT_YET_RECRUITING
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a CLPP binder may also engage these)

Protein	Name	Similarity
Q2KHU4	—	1.000	Q2KHU4 →
O88696	—	1.000	O88696 →
Q5N1P6	—	0.982	Q5N1P6 →
O34125	—	0.981	O34125 →
Q2S2L8	—	0.976	Q2S2L8 →
Q8CGK3	—	0.976	Q8CGK3 →
Q9F315	—	0.976	Q9F315 →
Q924S5	—	0.976	Q924S5 →
Q2G3T3	—	0.976	Q2G3T3 →
Q5Z062	—	0.975	Q5Z062 →
LONP1	Lon protease homolog, mitochondrial	0.975	landscape →
Q59HJ6	—	0.975	Q59HJ6 →
Q82CA6	—	0.974	Q82CA6 →
Q27539	—	0.974	Q27539 →
A8WPG6	—	0.974	A8WPG6 →
Q9FN42	—	0.973	Q9FN42 →
Q8TB37	—	0.973	Q8TB37 →
Q8DLI2	—	0.972	Q8DLI2 →
Q4FQB9	—	0.972	Q4FQB9 →
Q1GPH5	—	0.972	Q1GPH5 →
Q3ATL3	—	0.972	Q3ATL3 →
Q8YQX8	—	0.972	Q8YQX8 →
Q87YR6	—	0.972	Q87YR6 →
Q8KC73	—	0.972	Q8KC73 →
Q6G3Z3	—	0.972	Q6G3Z3 →
Q2J9A8	—	0.971	Q2J9A8 →
A2YQ56	—	0.971	A2YQ56 →
C4K4P2	—	0.971	C4K4P2 →
Q135W7	—	0.971	Q135W7 →
Q1RJH2	—	0.971	Q1RJH2 →