COX15 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to COX15 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R	PHASE4	WITHDRAWN
Assessment of the Response to Etoricoxib in Patients With Ankylosing Spondylitis and Inadequate Response to ≥2 NSAIDs	PHASE3	COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Deoxynucleosides Pyrimidines as Treatment for Mitochondrial Depletion Syndrome	PHASE2	RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Does Heme Oxygenase-1 Induction Ameliorate Cardiac Injury After Myocardial Infarction?	PHASE1/PHASE2	COMPLETED
Study of Gene Therapy Using a Lentiviral Vector to Treat X-linked Chronic Granulomatous Disease	PHASE1/PHASE2	COMPLETED
The KHENERGY Study	PHASE2	COMPLETED
Mitochondrial Function of Immune Cells in Sepsis	nan	COMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Hyperbaric Oxygen Therapy for Post Traumatic Stress Disorder	nan	COMPLETED
Mitoferrin-1 Expression in Erythropoietic Protoporphyria (Porphyria Rare Disease Clinical Research Consortium (RDCRC))	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Effect Inhaled Nitric Oxide in Adult Liver Transplant	nan	NOT_YET_RECRUITING
Use of GDF15 as a Biomarker for Early Diagnosis of DM and Monitoring of Progress of Complications in Asians	nan	UNKNOWN
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
European Survey: Risk of Cyanide Poisoning in Smoke Inhalation	nan	COMPLETED
Human Adaptation to High Altitude	nan	UNKNOWN
Role of Heme Oxygenase in the Pathogenesis of Hepatocellular Injury in Chronic Hepatitis C Virus (HCV) Infection	nan	UNKNOWN
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
DNA QUANTIFICATION TECHNIQUE AS A INTERPRETATION TOOL IN MITOCHONDRIAL DISEASES	nan	COMPLETED
The Crosstalk Between the Epigenome and Mitochondria in SCI	nan	NOT_YET_RECRUITING
Parkinson's Diseases Susceptibility Genes and Pesticides	nan	COMPLETED
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Pilot Study to Evaluate the Safety, Tolerability, and Efficacy of 5-ALA-Phosphate + SFC as an Immune System Enhancer Along With Vaccination Against COVID-19	nan	WITHDRAWN
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Collection of Blood and Skin Samples From Patients With Primary Mitochondrial Diseases and Healthy Volunteers	nan	RECRUITING
Studies in Porphyria I: Characterization of Enzyme Defects	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a COX15 binder may also engage these)

Protein	Name	Similarity
Q08DG6	—	1.000	Q08DG6 →
Q8BJ03	—	0.997	Q8BJ03 →
Q9FKT8	—	0.961	Q9FKT8 →
P40086	—	0.955	P40086 →
Q2Y9R4	—	0.954	Q2Y9R4 →
Q82X64	—	0.946	Q82X64 →
Q6AZR3	—	0.944	Q6AZR3 →
Q0AIG6	—	0.943	Q0AIG6 →
Q8R2R1	—	0.943	Q8R2R1 →
B6IUZ7	—	0.942	B6IUZ7 →
F1QF89	—	0.942	F1QF89 →
Q64I00	—	0.941	Q64I00 →
Q64HZ9	—	0.940	Q64HZ9 →
P00367	—	0.940	P00367 →
Q2W552	—	0.940	Q2W552 →
Q64HZ8	—	0.939	Q64HZ8 →
Q8BMF3	—	0.939	Q8BMF3 →
Q64I01	—	0.938	Q64I01 →
CYC1	Cytochrome c1, heme protein, mitochondrial	0.938	landscape →
Q14332	—	0.938	Q14332 →
Q9ER88	—	0.937	Q9ER88 →
P49448	—	0.937	P49448 →
A7HXA1	—	0.937	A7HXA1 →
P42174	—	0.937	P42174 →
P26443	—	0.936	P26443 →
Q499N4	—	0.936	Q499N4 →
B3DIG4	—	0.936	B3DIG4 →
Q9IA06	—	0.936	Q9IA06 →
P00125	—	0.936	P00125 →
Q9Y6A1	—	0.936	Q9Y6A1 →