CTPS2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL21044129	1.00	4/20
SCHEMBL21044574	1.00	4/20
SCHEMBL21044582	1.00	4/20
SCHEMBL21044469	0.93	4/20
SCHEMBL22491643	0.93	4/20
SCHEMBL22491639	0.86	4/20
SCHEMBL22491661	0.85	4/20
SCHEMBL22491627	0.84	4/20
SCHEMBL21044088	0.83	4/20
SCHEMBL21044169	0.82	4/20
SCHEMBL22491652	0.82	4/20
SCHEMBL21044294	0.82	4/20
SCHEMBL22491663	0.82	4/20
SCHEMBL21044285	0.82	4/20
SCHEMBL22491697	0.82	4/20
SCHEMBL21044297	0.82	4/20
SCHEMBL21044002	0.81	4/20
SCHEMBL21044583	0.81	4/20
SCHEMBL21044170	0.81	4/20
SCHEMBL21044334	0.81	4/20

Clinical trials — most relevant to CTPS2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy	PHASE2/PHASE3	UNKNOWN
Hereditary Sensory Neuropathy Serine Trial	PHASE2	UNKNOWN
A Phase II Study of TX Regimen as First-line Treatment for Asian Elderly Patients With Advanced Adenocarcinoma of Lung	PHASE2	COMPLETED
Prospective Phase II Randomized Trial of Postoperative Adjuvant Chemotherapy in Patients With High Risk Colon Cancer	PHASE2	UNKNOWN
Docetaxel Versus Docetaxel Plus Cisplatin Versus Docetaxel Plus S-1 as Second-line Chemotherapy in Metastatic Gastric Cancer	PHASE2	UNKNOWN
Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma	PHASE1/PHASE2	RECRUITING
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
TS Overexpression in SCLC: Mechanism and Therapeutic Targeting	nan	COMPLETED
Identification of a New Gene Involved in Hereditary Lipodystrophy	nan	COMPLETED
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes	nan	RECRUITING
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
Screening of Healthy Adults for Genetic Variations That Control Fatty Acid Processing	nan	COMPLETED
Gene Expression in Obesity and Insulin Resistance	nan	COMPLETED
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study	nan	COMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects	nan	UNKNOWN
Genetic and Metabolic Disease in Children	nan	RECRUITING
Endothelial Colony-Forming Cells in Patients With VWD, AVWS and Healthy Subjects	nan	RECRUITING
Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis	nan	COMPLETED
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
Lipidomic and Multi-Omics Profiling of Fatty Liver Disease in People With and Without HIV	nan	NOT_YET_RECRUITING
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children	nan	WITHDRAWN
Dietary Fatty Acids, PPAR Activated Genes, and CHD	nan	COMPLETED
Identifying Genetic Causes of IC/BPS	nan	RECRUITING
Genetic and Environmental Determinants of Triglycerides (GOLDN)	nan	COMPLETED
Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome	nan	RECRUITING
Genomewide Search for Loci Underlying Metabolic Syndrome	nan	COMPLETED
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a CTPS2 binder may also engage these)

Protein	Name	Similarity
Q1RMS2	—	1.000	Q1RMS2 →
Q5F3Z1	—	1.000	Q5F3Z1 →
Q5U2N0	—	1.000	Q5U2N0 →
Q7ZXP9	—	1.000	Q7ZXP9 →
Q6FUD0	—	1.000	Q6FUD0 →
Q5XHA8	—	1.000	Q5XHA8 →
Q5GTB4	—	1.000	Q5GTB4 →
A6ZQ59	—	1.000	A6ZQ59 →
P38627	—	1.000	P38627 →
Q3ANY4	—	1.000	Q3ANY4 →
P70303	—	1.000	P70303 →
Q54V77	—	1.000	Q54V77 →
Q6MD01	—	1.000	Q6MD01 →
Q9VUL1	—	1.000	Q9VUL1 →
B9KHF1	—	1.000	B9KHF1 →
P28274	—	1.000	P28274 →
B0JU82	—	1.000	B0JU82 →
Q822T2	—	0.999	Q822T2 →
Q5L5S1	—	0.999	Q5L5S1 →
Q254V9	—	0.999	Q254V9 →
B4SAT4	—	0.999	B4SAT4 →
P59040	—	0.999	P59040 →
Q5PBX6	—	0.998	Q5PBX6 →
Q7VGH1	—	0.998	Q7VGH1 →
B2SFK1	—	0.998	B2SFK1 →
O85347	—	0.998	O85347 →
Q6GME1	—	0.998	Q6GME1 →
A0M3I8	—	0.998	A0M3I8 →
B4S3A5	—	0.998	B4S3A5 →
A4IZP3	—	0.998	A4IZP3 →