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CX3CR1

CX3C chemokine receptor 1 · P49238 · CX3CR1 on Sugi Atlas →

9,019 patent compounds predicted against CX3CR1, 7,356 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL212266 SCHEMBL212266 1.00 20/20
Azd-8797 Azd-8797 (SCHEMBL212398) 1.00 20/20
Azd-8797 Azd-8797 (SCHEMBL212862) 1.00 20/20
SCHEMBL213021 SCHEMBL213021 1.00 20/20
Azd-8797 Azd-8797 (SCHEMBL213194) 1.00 20/20
SCHEMBL215431 SCHEMBL215431 1.00 20/20
SCHEMBL213043 SCHEMBL213043 0.83 20/20
SCHEMBL212895 SCHEMBL212895 0.82 20/20
SCHEMBL213257 SCHEMBL213257 0.82 20/20
SCHEMBL215568 SCHEMBL215568 0.80 20/20
SCHEMBL213184 SCHEMBL213184 0.80 20/20
SCHEMBL214184 SCHEMBL214184 0.80 20/20
SCHEMBL215321 SCHEMBL215321 0.80 20/20
SCHEMBL212063 SCHEMBL212063 0.79 20/20
SCHEMBL213617 SCHEMBL213617 0.79 20/20
SCHEMBL215703 SCHEMBL215703 0.79 20/20
SCHEMBL214279 SCHEMBL214279 0.78 20/20
SCHEMBL213475 SCHEMBL213475 0.76 20/20
SCHEMBL213496 SCHEMBL213496 0.76 20/20
SCHEMBL213969 SCHEMBL213969 0.76 20/20

Clinical trials — most relevant to CX3CR1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Renoprotection by Pentoxifylline and Angiotensin Receptor Blocker in Chronic Kidney Disease (CKD) PHASE4UNKNOWN
Leronlimab in Patients With Coronavirus Disease 2019 (COVID-19) With Need for Mechanical Ventilation or Extracorporeal Membrane Oxygenation PHASE3SUSPENDED
Efficacy of Ibuprofen Chronotherapy in Healing After Surgical Extraction of the Mandibular Third Molar PHASE2/PHASE3UNKNOWN
Leronlimab in Moderately Ill Patients With COVID-19 Pneumonia PHASE3SUSPENDED
Safety Study of a Chemokine Receptor (CXCR4) Antagonist in Multiple Myeloma Patients PHASE1/PHASE2COMPLETED
NOX-A12 in Combination With Bortezomib and Dexamethasone in Relapsed Multiple Myeloma PHASE2COMPLETED
Quantitating the Impact of Plerixafor PHASE1/PHASE2UNKNOWN
Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese Encephalitis PHASE2COMPLETED
Effect of Cenicriviroc on HIV Neurocognitive Impairment PHASE2COMPLETED
A Phase I Trial Anti-CC Chemokine Receptor 4 Chimeric Antigen Receptor T Cells (CCR4 CAR T Cells) for CCR4 Expressing T-cell Malignancies Including Peripheral T-cell Non-Hodgkin Lymphoma (PTCL) and Cutaneous T-cell Non-Hodgkin Lymphoma (CTCL) PHASE1RECRUITING
The Effects of Sleeve Gastrectomy on Fractalkine nanCOMPLETED
Fractalkine, a CX3C Chemokine, Act as a Mediator of Ocular Angiogenesis nanCOMPLETED
Evaluating the Role of Pre-existing Resolvins in the Resolution of ICU Delirium nanWITHDRAWN
The Role of SDF-1/CXCR4 in Metastasis of Oral Squamous Cell Carcinoma nanUNKNOWN
Characterization of Microbiological and Genetic Features in Prostate Cancer and Their Association with Disease Stage nanENROLLING_BY_INVITATION
The Role of MMPs in the CXCL12-Induced Invasion of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma nanUNKNOWN
Role of CX3CR1-expressing Cells in Hematologic Malignancy nanUNKNOWN
Genetic Polymorphism Associated With Coronary Heart Disease Susceptibility and Variability of Clopidogrel Response nanACTIVE_NOT_RECRUITING
C-X-C Chemokine Receptor 4 in Chronic Lymphocytic Leukemia nanUNKNOWN
Evaluating Urinary CXCL10 for Enhanced Detection of Acute Rejection in Kidney Transplant Patients With Low DD-CFDNA nanRECRUITING
Nivolumab in mRCC Patients: Treg Function, T-cell Access and NK Interactions to Predict and Improve Efficacy nanCOMPLETED
Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity nanNOT_YET_RECRUITING
Involvement of Skeletal Muscle Fibrocytes in sarcOpenia in Patients With Chronic ObstRuctive Pulmonary Disease nanCOMPLETED
Comparative Study Between Alzheimer's and Multi-infarct Dementia nanUNKNOWN
Preoperative Risk Factors and Perioperative Neurocognitive Disorders nanCOMPLETED
The Role of Cxcr4Hi neutrOPhils in InflueNza nanRECRUITING
Impact of Post-ARDS Covid-19 Sedation on Persistent Neuroinflammation nanRECRUITING
A Study That Collects Participant Data and Biospecimens to Analyze Pathogenic Exosomes That Mediate Increased Vascular Dementia Risk in Individuals With Herpes Zoster. nanRECRUITING
Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker nanCOMPLETED
The Role of Neutrophil CD64 and Soluble Triggering Receptor Expressed on Myeloid Cells 1 in Neonatal Sepsis nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a CX3CR1 binder may also engage these)

ProteinNameSimilarity
Q2KTE1 — 1.000 Q2KTE1 →
P35411 — 1.000 P35411 →
A6QNL7 — 1.000 A6QNL7 →
Q9Z0D9 — 1.000 Q9Z0D9 →
O54814 — 0.999 O54814 →
Q2Y2P0 — 0.997 Q2Y2P0 →
Q9TSQ8 — 0.996 Q9TSQ8 →
Q9BDS8 — 0.996 Q9BDS8 →
Q9Z2I3 — 0.996 Q9Z2I3 →
Q3LSL6 — 0.996 Q3LSL6 →
CXCR4 C-X-C chemokine receptor type 4 0.995 landscape →
P51676 — 0.995 P51676 →
Q9N0Z0 — 0.995 Q9N0Z0 →
Q95ND1 — 0.995 Q95ND1 →
Q64H34 — 0.995 Q64H34 →
Q95NC6 — 0.995 Q95NC6 →
Q6WN98 — 0.995 Q6WN98 →
Q9XT45 — 0.995 Q9XT45 →
Q9YGC3 — 0.995 Q9YGC3 →
O18983 — 0.995 O18983 →
P56493 — 0.995 P56493 →
Q764M9 — 0.995 Q764M9 →
P56498 — 0.995 P56498 →
Q95NC4 — 0.995 Q95NC4 →
Q95NC2 — 0.995 Q95NC2 →
P56491 — 0.995 P56491 →
CCR1 C-C chemokine receptor type 1 0.995 landscape →
P56482 — 0.994 P56482 →
P79394 — 0.994 P79394 →
P25930 — 0.994 P25930 →