DACH1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to DACH1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Pharmacogenetics of Disulfiram for Cocaine	PHASE2	COMPLETED
A Phase II Study of Bevacizumab and Erlotinib in Subjects With Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell Cancer	PHASE2	COMPLETED
Nivolumab With Vismodegib in Patients With Basal Cell Nevus Syndrome	PHASE2	WITHDRAWN
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome	PHASE1	COMPLETED
Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC)	PHASE1	COMPLETED
FOLFIRINOX Plus IPI-926 for Advanced Pancreatic Adenocarcinoma	PHASE1	COMPLETED
Phase I Study of Gene Induction Mediated by Sequential Decitabine/Depsipeptide Infusion With or Without Concurrent Celecoxib in Subjects With Pulmonary and Pleural Malignancies	PHASE1	COMPLETED
The PAH Platform for Deep Phenotyping in Korean Subjects	nan	UNKNOWN
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science	nan	RECRUITING
Genetic Study of Patients With Primary Ciliary Dyskinesia	nan	COMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Inherited Reproductive Disorders	nan	RECRUITING
Human Epilepsy Genetics--Neuronal Migration Disorders Study	nan	RECRUITING
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia	nan	UNKNOWN
Evaluation of rhGH Replacement Therapy in Patients With Pseudohypoparathyroidism Type Ia (PHP Ia)	nan	UNKNOWN
PCD New Gene Discovery	nan	COMPLETED
Genetic Basis of Non Syndromic Congenital Diaphragmatic Hernia	nan	COMPLETED
Evaluation of Phenotypic and Genetic Properties in Male Subjects Affected By Hypohidrotic Ectodermal Dysplasia	nan	COMPLETED
Hormonal Regulation of Puberty and Fertility	nan	COMPLETED
SS-HH-OCT as a Novel Diagnostic Modality for Early-Onset Retinal Dystrophies (EORDs)	nan	RECRUITING
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve	nan	UNKNOWN
Study of Skeletal Disorders and Short Stature	nan	COMPLETED
Genetics of Primary Ciliary Dyskinesia	nan	COMPLETED
Inherited Genetic Susceptibility in Langerhans Cell Histiocytosis (LCH)	nan	ACTIVE_NOT_RECRUITING
CDH1 Germline Mutations in Lobular Breast Cancer	nan	COMPLETED
X-Linked Hypohidrotic Ectodermal Dysplasia (XLHED) Carrier Outlook Toward Reproduction Survey	nan	COMPLETED
Hirschsprung Disease Genetic Study	nan	RECRUITING
Genetic Clues to Chordoma Etiology: A Protocol to Identify Sporadic Chordoma Patients for Studies of Cancer-Susceptibility Genes	nan	ACTIVE_NOT_RECRUITING
A Study Providing Genetic Testing to Find Those Who May Have Primary Ciliary Dyskinesia for Potential Clinical Trials	nan	ACTIVE_NOT_RECRUITING
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a DACH1 binder may also engage these)

Protein	Name	Similarity
Q9QYB2	—	1.000	Q9QYB2 →
Q9VW27	—	0.998	Q9VW27 →
P40645	—	0.998	P40645 →
P40647	—	0.997	P40647 →
Q5RCU4	—	0.997	Q5RCU4 →
Q03372	—	0.996	Q03372 →
Q62431	—	0.995	Q62431 →
Q96NX9	—	0.995	Q96NX9 →
Q90XB3	—	0.995	Q90XB3 →
A0A0G2JTZ2	—	0.995	A0A0G2JTZ2 →
P06602	—	0.995	P06602 →
Q5QL03	—	0.995	Q5QL03 →
P22265	—	0.994	P22265 →
P0CF24	—	0.994	P0CF24 →
Q6YHU8	—	0.994	Q6YHU8 →
Q9NSC2	—	0.994	Q9NSC2 →
Q925Q8	—	0.994	Q925Q8 →
Q80TZ9	—	0.994	Q80TZ9 →
Q95RW8	—	0.994	Q95RW8 →
Q4VYR7	—	0.994	Q4VYR7 →
O35762	—	0.994	O35762 →
P16376	—	0.994	P16376 →
P23899	—	0.994	P23899 →
A2BEA6	—	0.994	A2BEA6 →
Q9YGK8	—	0.994	Q9YGK8 →
Q06453	—	0.994	Q06453 →
Q58NQ4	—	0.993	Q58NQ4 →
Q6EUW2	—	0.993	Q6EUW2 →
Q91660	—	0.993	Q91660 →
Q9QYE3	—	0.993	Q9QYE3 →