DARS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to DARS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Bezafibrate Trial in CPT2 Deficiency	PHASE3	UNKNOWN
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC	PHASE2	COMPLETED
Safety and Tolerance of RAG-17 in Amyotrophic Lateral Sclerosis Patients With SOD1 Gene Mutation	EARLY_PHASE1	COMPLETED
Quantifying Disease Progression in LBSL	nan	UNKNOWN
Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)	nan	RECRUITING
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Impact of Seasonal Malaria Chemoprevention on Immunity Against Malaria Among Children in Northern Benin	nan	COMPLETED
Genomic of CONgenital Sideroblastic Anemias	nan	RECRUITING
Natural History Study of FDXR Mutation-related Mitochondriopathy	nan	COMPLETED
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models	nan	COMPLETED
Calf Muscle Strength in Mitochondrial Diseases	nan	COMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes	nan	RECRUITING
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants	nan	RECRUITING
Protein Synthesis in the Brain of Patients With Fragile X Syndrome	nan	COMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Diagnosis and Phenotype Characterisation Using Genomics in Patients With Inherited Bone Marrow Failure (IBMDx Study)	nan	RECRUITING
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases	nan	COMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Identification of a New Gene Involved in Hereditary Lipodystrophy	nan	COMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a DARS1 binder may also engage these)

Protein	Name	Similarity
Q3SYZ4	—	1.000	Q3SYZ4 →
Q5R9I5	—	1.000	Q5R9I5 →
Q922B2	—	1.000	Q922B2 →
P15178	—	0.999	P15178 →
Q03577	—	0.988	Q03577 →
Q9M084	—	0.988	Q9M084 →
P58697	—	0.987	P58697 →
Q1CGI7	—	0.987	Q1CGI7 →
A7GTK8	—	0.987	A7GTK8 →
Q6MEC9	—	0.986	Q6MEC9 →
O74407	—	0.986	O74407 →
A1JMN8	—	0.986	A1JMN8 →
A4TMZ6	—	0.985	A4TMZ6 →
Q0HIB6	—	0.984	Q0HIB6 →
Q6HCW9	—	0.984	Q6HCW9 →
Q0HUL3	—	0.984	Q0HUL3 →
P04802	—	0.984	P04802 →
Q8H104	—	0.984	Q8H104 →
P0A8M0	—	0.984	P0A8M0 →
Q0T6B1	—	0.984	Q0T6B1 →
P0A8M2	—	0.984	P0A8M2 →
Q0TJC3	—	0.984	Q0TJC3 →
A0KXL6	—	0.984	A0KXL6 →
B0BP90	—	0.984	B0BP90 →
P52276	—	0.983	P52276 →
A1RK52	—	0.983	A1RK52 →
Q22099	—	0.983	Q22099 →
A4Y6E4	—	0.983	A4Y6E4 →
Q8EEZ1	—	0.983	Q8EEZ1 →
Q1CA47	—	0.983	Q1CA47 →