Sugi Predict

Sugi Predict / Targets / DDC

DDC

Aromatic-L-amino-acid decarboxylase · P20711 · DDC on Sugi Atlas →

0 patent compounds predicted against DDC, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to DDC by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Comparison of Dopamin Level in Idiopathic Parkinson's Patients PHASE4UNKNOWN
Efficacy and Safety of Opicapone in Clinical Practice PHASE4COMPLETED
The SUSTAIN Study Compares the Effects of Sustained and Immediate-release Pramipexole on the noctUrnal Symptoms of paTients With Advanced ParkInsoN's Disease Who Also Take L-Dopa PHASE4COMPLETED
A Trial to Evaluate Safety and Efficacy of a Product Named VGN-R09b in Severe AADC Deficiency PHASE2/PHASE3ACTIVE_NOT_RECRUITING
Carbidopa for the Treatment of Nausea and Vomiting in Familial Dysautonomia PHASE3COMPLETED
Efficacy and Safety of BIA 9-1067 in Idiopathic Parkinson's Disease Patients With Wearing-off Phenomenon PHASE3COMPLETED
Efficacy and Safety of BIA 9-1067 in Idiopathic Parkinson's Disease Patients. PHASE3COMPLETED
A Trial of CM-AT in Children With Autism With All Levels of FCT (The Blum Study) PHASE3COMPLETED
Dopaminergic restauratIon by intraVEntriculaire Administration PHASE1/PHASE2COMPLETED
Study To Assess The Clinical Benefit Of Droxidopa And Droxidopa/Carbidopa In Subjects With Fibromyalgia PHASE2COMPLETED
High and Low Dose Carbidopa Treatment of Parkinson's Disease PHASE2COMPLETED
Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease. PHASE1/PHASE2RECRUITING
A Phase I/II Clinical Trial for Treatment of Aromatic L-amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC PHASE1/PHASE2COMPLETED
Mucuna Pruriens Therapy in Parkinson's Disease PHASE2COMPLETED
Efficacy and Tolerability of Nebicapone in Parkinson's Disease Patients With Wearingoff Phenomenon PHASE2COMPLETED
Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders PHASE2COMPLETED
A Single-Stage, Adaptive, Open-label, Dose Escalation Safety and Efficacy Study of AADC Deficiency in Pediatric Patients PHASE1RECRUITING
Safety Study of AADC Gene Therapy (VY-AADC01) for Parkinson's Disease PHASE1COMPLETED
Safety and Efficacy Study of VY-AADC01 for Advanced Parkinson's Disease PHASE1COMPLETED
A Study of AAV-hAADC-2 in Subjects With Parkinson's Disease PHASE1COMPLETED
Lu AF28996 in Participants With Parkinson's Disease (PD) PHASE1COMPLETED
An Early Clinical Trial to Evaluate VGN-R09b for Treatment of Aromatic L-amino Acid Decarboxylase (AADC) Deficiency. EARLY_PHASE1RECRUITING
Prevalence of High Plasmatic 3OMethyldopa Level in a Specific Population of Patients With a Symptomatology Compatible With AADC Deficiency nanUNKNOWN
Newborn Screening for Aromatic L-amino Acid Decarboxylase Deficiency nanCOMPLETED
AADC/TDC in Advanced Parkinson's Disease nanCOMPLETED
Nutritional Impacts of Palynziq on Patients With Phenylketonuria (PKU) nanRECRUITING
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione nanCOMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD nanUNKNOWN
Long-read Genome Sequencing for the Molecular Diagnosis of Dystonia nanRECRUITING
Acute Glycine Pharmacodynamic Study nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a DDC binder may also engage these)

ProteinNameSimilarity
P14173 — 1.000 P14173 →
P80041 — 1.000 P80041 →
A0A2H5AIY0 — 0.998 A0A2H5AIY0 →
P27718 — 0.997 P27718 →
O88533 — 0.997 O88533 →
Q06086 — 0.996 Q06086 →
Q7XHL3 — 0.996 Q7XHL3 →
P93083 — 0.994 P93083 →
P17770 — 0.993 P17770 →
P48861 — 0.991 P48861 →
Q64611 — 0.991 Q64611 →
Q9DBE0 — 0.990 Q9DBE0 →
P18486 — 0.989 P18486 →
Q8RY79 — 0.989 Q8RY79 →
P05031 — 0.988 P05031 →
O96567 — 0.988 O96567 →
P22781 — 0.987 P22781 →
A0AA51Z3J4 — 0.987 A0AA51Z3J4 →
A0A2H5AIY2 — 0.986 A0A2H5AIY2 →
P54770 — 0.986 P54770 →
O96569 — 0.985 O96569 →
Q9Y600 — 0.984 Q9Y600 →
A0A565D477 — 0.984 A0A565D477 →
A7SCH8 — 0.984 A7SCH8 →
P54769 — 0.984 P54769 →
Q9M0G4 — 0.984 Q9M0G4 →
P54768 — 0.984 P54768 →
O96571 — 0.984 O96571 →
Q06085 — 0.983 Q06085 →
Q0ZS27 — 0.983 Q0ZS27 →