DECR1

2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

0 patent compounds predicted against DECR1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Germline variants in DECR1 on Sugi Variant → ClinVar classifications, population frequency, and predictor agreement (AlphaMissense, SaProt, REVEL) Full DECR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

Clinical trials — most relevant to DECR1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Statin and Ezetimibe Association on Kinetics of Artificial Chilomicrons	PHASE4	COMPLETED
Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes	PHASE4	UNKNOWN
The Effect of Calcium and Vitamin D Supplements on Metabolic and Hormonal Disturbances in Polycystic Ovary Syndrome Patients	PHASE3	COMPLETED
Androgen Ablation Therapy With or Without Chemotherapy in Treating Patients With Metastatic Prostate Cancer	PHASE3	COMPLETED
Safety and Efficacy of Lapaquistat Acetate Taken Alone and With Atorvastatin in Subjects With Primary Dyslipidemia	PHASE3	COMPLETED
Smith-Lemli-Opitz Syndrome and Cholic Acid	PHASE1/PHASE2	COMPLETED
Toxicity and Efficacy Evaluation of Topical Minoxidil in Acne Vulgaris	PHASE1/PHASE2	UNKNOWN
Dose-Ranging Study for Miconazole Oil for Treatment of Otomycosis	PHASE2	COMPLETED
Vitamin D Intervention Trial in Healthy Chinese, Phase II	PHASE1	COMPLETED
Efavirenz for Patients With Alzheimer's Disease	PHASE1	COMPLETED
A Long-Term Study of Cholesterol Supplements for Smith-Lemli-Opitz Syndrome	nan	WITHDRAWN
Replacement of Vitamin D in Patients With Active Tuberculosis	nan	COMPLETED
Study of Smith-Lemli-Opitz Syndrome	nan	COMPLETED
Gene Polymorphisms Influencing Steroid Synthesis and Action	nan	WITHDRAWN
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages	nan	COMPLETED
Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas	nan	UNKNOWN
Gene Expression in Obesity and Insulin Resistance	nan	COMPLETED
Mechanisms of Glucose Lowering Effect of Colesevelam HCl	nan	COMPLETED
Genetic Association of Diabetic Retinopathy-1	nan	UNKNOWN
Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome	nan	COMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
Steroid Treatment of Idiopathic Nephrotic Syndrome	nan	COMPLETED
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study	nan	COMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Urinary DENND1A.V2 as a Predictor of Pubertal Hyperandrogenemia	nan	SUSPENDED
Genetic, Dietary and Environmental Influences on Vitamin D Metabolism	nan	COMPLETED
Prenatal Screening For Smith-Lemli-Opitz Syndrome	nan	COMPLETED
S0424 - Carcinogens in Lung Tissue From Smokers (Closed to Entry as of 7/15/07) and Non-Smokers With Newly Diagnosed Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer	nan	COMPLETED
11C-Acetate PET/CT Non-FDG-Avid Tumors	nan	UNKNOWN
Omics-based Predictors of NAFLD/Potential NASH	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a DECR1 binder may also engage these)

Protein	Name	Similarity
Q9CQ62	—	1.000	Q9CQ62 →
Q64591	—	0.998	Q64591 →
Q22230	—	0.994	Q22230 →
Q93761	—	0.991	Q93761 →
Q23116	—	0.989	Q23116 →
Q9WVK3	—	0.989	Q9WVK3 →
P32573	—	0.987	P32573 →
Q9BY49	—	0.986	Q9BY49 →
Q02207	—	0.986	Q02207 →
Q9LTV6	—	0.985	Q9LTV6 →
A0A075TRB3	—	0.984	A0A075TRB3 →
Q9Z2M4	—	0.984	Q9Z2M4 →
Q9JIF5	—	0.984	Q9JIF5 →
A0A1W5SR39	—	0.983	A0A1W5SR39 →
L0E4F8	—	0.983	L0E4F8 →
Q6NV34	—	0.982	Q6NV34 →
A0A1B2CTA9	—	0.982	A0A1B2CTA9 →
Q9WV68	—	0.981	Q9WV68 →
Q5RCH8	—	0.981	Q5RCH8 →
Q9FZ42	—	0.981	Q9FZ42 →
P27581	—	0.981	P27581 →
P22245	—	0.980	P22245 →
Q1RH28	—	0.980	Q1RH28 →
Q9MA93	—	0.980	Q9MA93 →
P22246	—	0.980	P22246 →
Q9VXJ0	—	0.979	Q9VXJ0 →
O24990	—	0.979	O24990 →
Q5RBV3	—	0.979	Q5RBV3 →
P51660	—	0.979	P51660 →
Q00671	—	0.979	Q00671 →