Sugi Predict

Sugi Predict / Targets / DGAT2

DGAT2

Diacylglycerol O-acyltransferase 2 · Q96PD7 · DGAT2 on Sugi Atlas →

30,081 patent compounds predicted against DGAT2, 15,313 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL347038 SCHEMBL347038 0.76 20/20
SCHEMBL348115 SCHEMBL348115 0.67 20/20
SCHEMBL346584 SCHEMBL346584 0.65 20/20
SCHEMBL346756 SCHEMBL346756 0.64 20/20
SCHEMBL347553 SCHEMBL347553 0.64 20/20
SCHEMBL348128 SCHEMBL348128 0.66 19/20
SCHEMBL348069 SCHEMBL348069 0.64 19/20
SCHEMBL348428 SCHEMBL348428 0.62 19/20
SCHEMBL348096 SCHEMBL348096 0.59 19/20
SCHEMBL366640 SCHEMBL366640 0.59 19/20
SCHEMBL346686 SCHEMBL346686 0.56 19/20
SCHEMBL347021 SCHEMBL347021 0.54 19/20
SCHEMBL347648 SCHEMBL347648 0.58 18/20
SCHEMBL1284557 SCHEMBL1284557 0.51 16/20
SCHEMBL1284559 SCHEMBL1284559 0.51 16/20
SCHEMBL346757 SCHEMBL346757 0.53 15/20
SCHEMBL347954 SCHEMBL347954 0.51 15/20
SCHEMBL1283557 SCHEMBL1283557 0.48 15/20
SCHEMBL1283558 SCHEMBL1283558 0.48 15/20
SCHEMBL1283767 SCHEMBL1283767 0.48 15/20

Clinical trials — most relevant to DGAT2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Omega 3 and Ischemic Stroke; Fish Oil as an Option PHASE4UNKNOWN
Role of Pioglitazone in the Treatment of Non-alcoholic Steatohepatitis (NASH) PHASE4COMPLETED
Mechanisms Underlying Metabolic Syndrome in Obesity PHASE4COMPLETED
Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate PHASE2/PHASE3WITHDRAWN
Vitamin E and DHA-EE on NAFLD - Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial (PUVENAFLD) PHASE2COMPLETED
Polyunsaturated Fatty Acids (PUFA) in Diabetic Fatty Liver PHASE2COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides PHASE1COMPLETED
Liver Positron Emission Tomography (PET) Study of Non Alcoholic Fatty Liver Disease EARLY_PHASE1COMPLETED
Evaluation of Botanicals for Mechanisms Related to Appetite and Fat Metabolism nanCOMPLETED
A 12 Week, 3-Period Study to Evaluate the Effects of a Dietary Supplement on Lipid Metabolism nanCOMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity. nanCOMPLETED
Free Fatty Acid Induced Insulin Resistance nanCOMPLETED
De Novo Lipogenesis in Severity of NAFLD nanCOMPLETED
Genetic Determinants:Low HDL, High Triglycerides, Obesity nanCOMPLETED
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children nanWITHDRAWN
Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine Patients nanCOMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish) nanUNKNOWN
Duality of Lipids: the Athlete's Paradox nanCOMPLETED
Muscle Fat Compartments and Turnover as Determinant of Insulin Sensitivity nanCOMPLETED
Tissue Lipids and Insulin Resistance nanWITHDRAWN
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia nanUNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Lipidomic and Multi-Omics Profiling of Fatty Liver Disease in People With and Without HIV nanNOT_YET_RECRUITING
Fat-induced Release of GLP-1 in Humans nanCOMPLETED
Healthy Fatty Acids in Transition nanCOMPLETED
Choline to Improve Malnutrition and Enhance Cognition nanRECRUITING
Effects of Fish Oils on Inflammation and Insulin Resistance nanCOMPLETED
Genetic and Environmental Determinants of Triglycerides (GOLDN) nanCOMPLETED
A Longitudinal Study on Short-term Effects of Gastric Bypass on Glucose Homeostasis in Obesity nanCOMPLETED
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a DGAT2 binder may also engage these)

ProteinNameSimilarity
Q5FVP8 — 1.000 Q5FVP8 →
Q9DCV3 — 1.000 Q9DCV3 →
Q70VZ8 — 0.998 Q70VZ8 →
Q6PAZ3 — 0.990 Q6PAZ3 →
Q6P342 — 0.989 Q6P342 →
Q4V9F0 — 0.981 Q4V9F0 →
Q70VZ7 — 0.980 Q70VZ7 →
Q96PD6 — 0.976 Q96PD6 →
Q80W94 — 0.975 Q80W94 →
MOGAT2 2-acylglycerol O-acyltransferase 2 0.975 landscape →
Q3KPP4 — 0.971 Q3KPP4 →
Q2KHS5 — 0.971 Q2KHS5 →
Q28C88 — 0.970 Q28C88 →
GNPAT Dihydroxyacetone phosphate acyltransferase 0.969 landscape →
Q8K3K7 — 0.969 Q8K3K7 →
P98192 — 0.968 P98192 →
G1SPE9 — 0.968 G1SPE9 →
Q91ZV4 — 0.968 Q91ZV4 →
Q5M8H5 — 0.967 Q5M8H5 →
Q1LWG4 — 0.966 Q1LWG4 →
Q9D1E8 — 0.966 Q9D1E8 →
A4IF87 — 0.965 A4IF87 →
Q9ES71 — 0.965 Q9ES71 →
Q9ASU1 — 0.963 Q9ASU1 →
Q5ZJD8 — 0.963 Q5ZJD8 →
Q8S8S2 — 0.963 Q8S8S2 →
Q9D850 — 0.963 Q9D850 →
Q8BYI6 — 0.962 Q8BYI6 →
Q8L4Y2 — 0.961 Q8L4Y2 →
K7K424 — 0.961 K7K424 →