DHPS — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4061454	0.83	20/20
SCHEMBL4064097	0.74	20/20
SCHEMBL4061451	0.58	19/20
SCHEMBL4066788	0.85	18/20
SCHEMBL2640206	0.62	18/20
SCHEMBL4061147	0.80	15/20
SCHEMBL4071996	0.67	15/20
SCHEMBL4060249	0.66	15/20
SCHEMBL1817177	0.57	15/20
SCHEMBL1257596	0.52	15/20
SCHEMBL1397098	0.51	15/20
SCHEMBL4062097	0.51	15/20
SCHEMBL4060945	0.71	14/20
SCHEMBL4066782	0.66	14/20
SCHEMBL1009078	0.63	14/20
SCHEMBL4061140	0.62	14/20
SCHEMBL4068803	0.61	14/20
SCHEMBL2490097	0.59	14/20
SCHEMBL618135	0.58	14/20
Phenetole (SCHEMBL2489884)	0.56	14/20

Clinical trials — most relevant to DHPS by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effectiveness of Seasonal Malaria Chemoprevention in Nampula Province, Mozambique: Type Two Hybrid Implementation Study	PHASE4	UNKNOWN
Efficacy of Antifolates Against Malaria in HIV-infected Pregnant Women and the Emergence of Induced Resistance in Plasmodium Falciparum	PHASE3	COMPLETED
A Long-Term Safety Study of PTC923 in Participants With Phenylketonuria	PHASE3	ACTIVE_NOT_RECRUITING
Prospective Phase II Randomized Trial of Postoperative Adjuvant Chemotherapy in Patients With High Risk Colon Cancer	PHASE2	UNKNOWN
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC	PHASE2	COMPLETED
Fosmidomycin With Clindamycin or With Clindamycin Plus Artesunate	PHASE2	WITHDRAWN
Docetaxel Versus Docetaxel Plus Cisplatin Versus Docetaxel Plus S-1 as Second-line Chemotherapy in Metastatic Gastric Cancer	PHASE2	UNKNOWN
Fosmidomycin and Azithromycin for Acute Uncomplicated Plasmodium Falciparum Malaria (P. Malaria) in Adults	PHASE2	UNKNOWN
Leflunomide or Combination of MEK Inhibitor and Hydroxychloroquine for Refractory Patients With RAS Mutations	PHASE2	RECRUITING
A Phase II Study of TX Regimen as First-line Treatment for Asian Elderly Patients With Advanced Adenocarcinoma of Lung	PHASE2	COMPLETED
NEO100 and High-Grade Meningioma	PHASE2	RECRUITING
Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer	PHASE2	COMPLETED
Pemetrexed in Combination With Erlotinib as a Salvage Treatment in Patients With Metastatic Biliary Tract Cancer (BTC) Who Failed Gemcitabine Containing Chemotherapy: A Phase II Single Arm Prospective Study	PHASE2	UNKNOWN
Simvastatin Therapy in Smith-Lemli-Opitz Syndrome	PHASE2	COMPLETED
Assessing the Safety and Tolerability of NMN in DHDDS-CDG	PHASE1	RECRUITING
A Phase I Trial of ZD1694 (TOMUDEX), an Inhibitor of Thymidylate Synthase, in Pediatric Patients With Advanced Neoplastic Disease	PHASE1	COMPLETED
Efficacy of Sunlight Activated Synthetic Porphyrin in COVID-19 Infected Patients	PHASE1	UNKNOWN
5-Fluoro-2'-Deoxcyctidine and Tetrahydrouridine to Treat Patients With Advanced Cancer	PHASE1	COMPLETED
SPK Study in Afghanistan	nan	COMPLETED
Prognostic Value of (DHODH) Expression in (HGSOC): A Comparative Study Between Neoadjuvant and Adjuvant Chemotherapy Settings	nan	NOT_YET_RECRUITING
Droplet Digital PCR and PCR-free BIOSensors for the Detection of Resistance-associated SNPs in Pneumocystis Jirovecii	nan	ACTIVE_NOT_RECRUITING
TIPTOP Sulfadoxine-pyrimethamine (SP) Drug Resistance Study	nan	COMPLETED
Mechanistic Studies of Teriflunomide in RRMS	nan	COMPLETED
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
Antimalarial Drug Resistance in Mali	nan	COMPLETED
TS Overexpression in SCLC: Mechanism and Therapeutic Targeting	nan	COMPLETED
Mutation Analysis of 17α-Hydroxylase	nan	UNKNOWN
Studies in Porphyria I: Characterization of Enzyme Defects	nan	UNKNOWN
Tumor Response to Pemetrexed Disodium in Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Enrolled in Clinical Trial MCCRC-RC0524	nan	COMPLETED
Treatment Efficacy and Malaria TRANSmission After Artemisinin Combination Therapy (TRANSACT)	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a DHPS binder may also engage these)

Protein	Name	Similarity
Q3TXU5	—	1.000	Q3TXU5 →
Q9SC14	—	1.000	Q9SC14 →
Q6AY53	—	1.000	Q6AY53 →
Q6RJS2	—	1.000	Q6RJS2 →
Q9FI94	—	1.000	Q9FI94 →
Q6EWQ6	—	1.000	Q6EWQ6 →
Q9SC80	—	0.999	Q9SC80 →
Q9VSF4	—	0.999	Q9VSF4 →
Q54MQ7	—	0.999	Q54MQ7 →
Q75EW4	—	0.998	Q75EW4 →
Q9AXQ8	—	0.996	Q9AXQ8 →
O94337	—	0.996	O94337 →
Q9AXR0	—	0.996	Q9AXR0 →
P49365	—	0.996	P49365 →
Q9XXJ0	—	0.996	Q9XXJ0 →
B8HNE7	—	0.995	B8HNE7 →
P60038	—	0.995	P60038 →
Q9M4B0	—	0.994	Q9M4B0 →
Q6BJH5	—	0.994	Q6BJH5 →
Q6CG56	—	0.994	Q6CG56 →
Q6CNG7	—	0.994	Q6CNG7 →
Q9SC13	—	0.993	Q9SC13 →
B2IZP9	—	0.993	B2IZP9 →
A9NCJ8	—	0.992	A9NCJ8 →
Q9AXQ9	—	0.992	Q9AXQ9 →
P38791	—	0.991	P38791 →
Q9AB72	—	0.990	Q9AB72 →
Q8DKP1	—	0.990	Q8DKP1 →
B3QLU4	—	0.990	B3QLU4 →
Q8YQL7	—	0.990	Q8YQL7 →