DIAPH1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to DIAPH1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome	PHASE3	COMPLETED
Antioxidant Therapy With N-acetylcysteine for Learning and Motor Behavior in Children With Neurofibromatosis Type 1	PHASE2	COMPLETED
Antioxidant Therapy With N-acetylcysteine for Children With Neurofibromatosis Type 1	PHASE2	COMPLETED
Combination Therapy (Mirdametinib and Sirolimus) for RAS Mutated Relapsed Refractory Multiple Myeloma	PHASE1/PHASE2	SUSPENDED
Study of ISM6331 in Participants With Advanced/Metastatic Malignant Mesothelioma or Other Solid Tumors	PHASE1	RECRUITING
Interleukin-2 Treatment for Wiskott-Aldrich Syndrome	PHASE1	COMPLETED
Evaluation of Formin Gene Status and Expression in Myeloproliferative and Myelodysplastic Disorders	nan	COMPLETED
Podocyts Integrity in Glomerular Diseases	nan	UNKNOWN
Genetic Study of Patients and Families With Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma of the Bone	nan	COMPLETED
Genetic Identification (ID) of Segmental Dysplastic Nevi	nan	WITHDRAWN
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia	nan	UNKNOWN
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science	nan	RECRUITING
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma	nan	RECRUITING
Study of Skeletal Disorders and Short Stature	nan	COMPLETED
Genetic Mechanisms and Additional Risk Factors Underlying Hip Dysplasia	nan	COMPLETED
The Activation of Hippo Pathway in Nasal Polyps	nan	UNKNOWN
Implication of Long Non-coding RNA CCDC144NL-AS1/Micro RNA-143-3p Axis Expression Level as Novel Signature in Colorectal Cancer	nan	COMPLETED
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve	nan	UNKNOWN
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients	nan	RECRUITING
Molecular Characterization of Spinal Tissue	nan	ENROLLING_BY_INVITATION
Observational Cohort Study of Dysferlinopathy in China	nan	COMPLETED
Development of Primary Cultures of Diaphragmatic Myoblasts for Basic Research Purposes	nan	NOT_YET_RECRUITING
Institution of an Italian Multicenter Database of Patients With Multiple Endocrine Neoplasia Type 1 (MENNET1 Database)	nan	NOT_YET_RECRUITING
A Retrospective Study to Determine the Incidence of NTRK Fusions. NTRK Study	nan	COMPLETED
Study of Blood Samples From Patients With Ewing Sarcoma and Their Relatives	nan	COMPLETED
Familial Intracranial Aneurysm Study II	nan	COMPLETED
Clinical Outcome Study for Dysferlinopathy	nan	UNKNOWN
Markers and Mechanisms of Macrovascular Disease in IDDM	nan	COMPLETED
B3 for NMD: Bench to Bedside and Back	nan	ENROLLING_BY_INVITATION
Aberrant Gene Expression Prostate Carcinoma	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a DIAPH1 binder may also engage these)

Protein	Name	Similarity
O08808	—	1.000	O08808 →
F1M775	—	0.998	F1M775 →
A2APV2	—	0.988	A2APV2 →
FMNL1	Formin-like protein 1	0.987	landscape →
F1LVW7	—	0.987	F1LVW7 →
Q9JL26	—	0.986	Q9JL26 →
Q6NTV6	—	0.985	Q6NTV6 →
Q6NXC0	—	0.984	Q6NXC0 →
A0A3Q1LSX9	—	0.984	A0A3Q1LSX9 →
Q96PY5	—	0.984	Q96PY5 →
Q9Z207	—	0.984	Q9Z207 →
Q6ZPF4	—	0.982	Q6ZPF4 →
Q86T65	—	0.982	Q86T65 →
Q8BMI3	—	0.981	Q8BMI3 →
Q8IVF7	—	0.981	Q8IVF7 →
Q0IHV1	—	0.981	Q0IHV1 →
Q6P2K6	—	0.981	Q6P2K6 →
PPP4R3A	Serine/threonine-protein phosphatase 4 regulatory subunit 3A	0.980	landscape →
Q0GNC1	—	0.979	Q0GNC1 →
Q6INN7	—	0.979	Q6INN7 →
Q9UJY5	—	0.978	Q9UJY5 →
Q9C6S1	—	0.978	Q9C6S1 →
P51432	—	0.978	P51432 →
Q5SP90	—	0.978	Q5SP90 →
Q9Y4D1	—	0.978	Q9Y4D1 →
Q99MP8	—	0.977	Q99MP8 →
B0DOB5	—	0.977	B0DOB5 →
Q41583	—	0.977	Q41583 →
Q9NSV4	—	0.976	Q9NSV4 →
Q8BPM0	—	0.976	Q8BPM0 →