DIS3

Exosome complex exonuclease RRP44 · Q9Y2L1 · DIS3 on Sugi Atlas →

0 patent compounds predicted against DIS3, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to DIS3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Reverse Transcriptase Inhibitors in AGS PHASE2COMPLETED
Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema PHASE2COMPLETED
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy nanUNKNOWN
Cell Free Circulating Nucleic Acids as New Tumor Diagnostics From Human Plasma Samples. nanUNKNOWN
B3 for NMD: Bench to Bedside and Back nanENROLLING_BY_INVITATION
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis nanCOMPLETED
The Value of circRNAs (hsa_circ_0004001) in Early Diagnosis of HCC nanUNKNOWN
A Study That Collects Participant Data and Biospecimens to Analyze Pathogenic Exosomes That Mediate Increased Vascular Dementia Risk in Individuals With Herpes Zoster. nanRECRUITING
Exosome of Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repaire of Acute Type A Aortic Dissection nanNOT_YET_RECRUITING
Liquid Biopsy for Early Detection of Colorectal Cancer Using Circular RNA nanRECRUITING
Smoker Extracellular Vesicles Influence on Human Bronchial Epithelial Cells nanCOMPLETED
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve nanUNKNOWN
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population nanCOMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia nanNOT_YET_RECRUITING
Study of Exosomes in Monitoring Patients With Sarcoma (EXOSARC) nanCOMPLETED
DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study nanRECRUITING
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing nanRECRUITING
Genetic Investigation of Cancer Predisposition nanNOT_YET_RECRUITING
Exosomal microRNAs as a Biomarker in Panic Disorder and in Response to CBT nanUNKNOWN
Impact of Weight Loss on the Human Sperm Epitranscriptome nanACTIVE_NOT_RECRUITING
Interest of High-throughput Sequencing of RNAs for the Diagnosis of Heterogeneous Genetic Diseases nanUNKNOWN
Diagnostic and Prognostic Value of MicroRNA in Breast Cancer Patients nanUNKNOWN
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact nanUNKNOWN
Screening of Lysosomal Storage Disorders Diseases in Minority Groups nanUNKNOWN
Expression and Clinical Significance of IGHD in Pancreatic Cancer nanUNKNOWN
miR-155 Expression in Episodic and Chronic Migraine nanUNKNOWN
Decoding Developmental Disorders in Humams nanCOMPLETED
New Biomarkers in Pancreatic Cancer Using EXPEL Concept nanRECRUITING
Micro RNAs to Predict Response to Androgen Deprivation Therapy nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a DIS3 binder may also engage these)

ProteinNameSimilarity
Q9CSH3 1.000 Q9CSH3 →
P37202 0.998 P37202 →
Q17632 0.996 Q17632 →
A0JN80 0.993 A0JN80 →
A2RV18 0.992 A2RV18 →
Q9SHL7 0.991 Q9SHL7 →
Q5U2P0 0.990 Q5U2P0 →
Q0P4R5 0.990 Q0P4R5 →
Q5R5N8 0.989 Q5R5N8 →
Q0V9R3 0.988 Q0V9R3 →
Q8TF46 0.988 Q8TF46 →
Q6GN11 0.986 Q6GN11 →
Q8C0S1 0.986 Q8C0S1 →
Q08162 0.983 Q08162 →
Q09568 0.983 Q09568 →
Q9UJA3 0.979 Q9UJA3 →
LIG4 DNA ligase 4 0.978 landscape →
NAT10 RNA cytidine acetyltransferase 0.978 landscape →
Q5XHY5 0.978 Q5XHY5 →
Q0V9S0 0.977 Q0V9S0 →
Q5R6L3 0.977 Q5R6L3 →
D3ZVK1 0.977 D3ZVK1 →
O42131 0.977 O42131 →
Q5F310 0.977 Q5F310 →
TARS1 Threonine--tRNA ligase 1, cytoplasmic 0.977 landscape →
Q32NH8 0.977 Q32NH8 →
G3GTP0 0.976 G3GTP0 →
Q6NUA1 0.976 Q6NUA1 →
Q3ZBV8 0.976 Q3ZBV8 →
A6QLJ3 0.976 A6QLJ3 →