DLD

Dihydrolipoyl dehydrogenase, mitochondrial · P09622 · DLD on Sugi Atlas →

0 patent compounds predicted against DLD, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to DLD by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: PHASE3ACTIVE_NOT_RECRUITING
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Clinical Effects of Alpha-Lipoic Acid in Advanced NSCLC PHASE2NOT_YET_RECRUITING
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI) PHASE2RECRUITING
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC PHASE2COMPLETED
Deoxynucleosides Pyrimidines as Treatment for Mitochondrial Depletion Syndrome PHASE2RECRUITING
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis PHASE2UNKNOWN
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
A Phase II Study of Bevacizumab and Erlotinib in Subjects With Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell Cancer PHASE2COMPLETED
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies nanRECRUITING
Fatty Acid Oxidation Defects and Insulin Sensitivity nanCOMPLETED
Prognostic Value of (DHODH) Expression in (HGSOC): A Comparative Study Between Neoadjuvant and Adjuvant Chemotherapy Settings nanNOT_YET_RECRUITING
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases nanCOMPLETED
Effect of Diaphragm Stimulation During Surgery nanCOMPLETED
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Mechanistic Studies of Teriflunomide in RRMS nanCOMPLETED
Nephroprotective Effects of Carnitine and (PDE5) Inhibitor Agent Against Contrast Media-induced Nephropathy (CMN) nanUNKNOWN
Natural History Study of Pyruvate Dehydrogenase Deficiency nanUNKNOWN
Supplementation With Alpha-lipoic Acid and Silybum Marianum(LUDLEV®) for the Improvement of Fatty Liver Disease nanUNKNOWN
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside nanUNKNOWN
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
Droplet Digital PCR and PCR-free BIOSensors for the Detection of Resistance-associated SNPs in Pneumocystis Jirovecii nanACTIVE_NOT_RECRUITING
Nutraceutical Composition Containing Natural Products Derivatives on the Modulation of the Endocrine Neuroimmune Axis nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a DLD binder may also engage these)

ProteinNameSimilarity
Q6P6R2 1.000 Q6P6R2 →
Q8CIZ7 1.000 Q8CIZ7 →
P49819 1.000 P49819 →
Q5R4B1 1.000 Q5R4B1 →
F1N206 1.000 F1N206 →
O08749 1.000 O08749 →
Q60HG3 1.000 Q60HG3 →
Q54EW8 1.000 Q54EW8 →
P09623 1.000 P09623 →
O00087 0.996 O00087 →
Q9M5K3 0.996 Q9M5K3 →
P31023 0.995 P31023 →
P09624 0.995 P09624 →
Q9SPB1 0.995 Q9SPB1 →
Q811C4 0.995 Q811C4 →
O17953 0.995 O17953 →
G0SB20 0.993 G0SB20 →
O18480 0.992 O18480 →
Q04933 0.991 Q04933 →
P39050 0.990 P39050 →
Q9M5K2 0.990 Q9M5K2 →
P52992 0.989 P52992 →
P39051 0.989 P39051 →
Q41219 0.989 Q41219 →
P28593 0.988 P28593 →
P13110 0.988 P13110 →
P90597 0.987 P90597 →
P14218 0.987 P14218 →
F4JLP5 0.987 F4JLP5 →
Q50068 0.987 Q50068 →